founder-mode-oncology SKILL.md skillA
founder-mode-oncology from broomva/skills is an agent skill: a SKILL.md folder an AI agent loads when a task calls for it.
mdr add broomva/skills/founder-mode-oncology@git:20260628.9edbf07Pins git:20260628.9edbf07 in mdr.lock. Pin the fingerprint instead.
- Audit grade
- A, 17 of 17 checks passed
- Kind
- SKILL.md skill
- Repository
- broomva/skills
- Path
skills/healthcare/founder-mode-oncology/SKILL.md- Versions recorded
- 1
- Latest version
- git:20260628.9edbf07, committed Jun 28, 2026
- Size
- 9,848 bytes
- Repository stars
- 5
- License
- MIT
Personalized cancer treatment navigation — maximal diagnostics, parallel therapy, therapeutic development, structure-based protein design. Use when (1) researching cancer treatments or combinations, (2) designing diagnostic strategies, (3) evaluating neoantigen vaccines or radioligand therapies, (4) navigating FDA expanded access or IRB processes, (5) interpreting ctDNA/MRD data, (6) building bioinformatics pipelines, (7) scRNA-seq target discovery, (8) AlphaFold/RFdiffusion/ProteinMPNN for…
Collected from public GitHub. Every version is saved exactly as it was and never changes. Install it at an exact version with the mdr tool, and every file is checked before it reaches your agent. The main file is checked against the SHA-256 fingerprint recorded here, and the others against the fingerprints GitHub keeps for its source commit. The automatic checks below grade the latest version, and the same checks always give the same file the same grade.
What the file says
# Founder Mode Oncology Systematic framework for navigating personalized cancer treatment, generalized from Sid Sijbrandij's osteosarcoma case (2022-2026). Transforms the ad-hoc "billionaire with a team" approach into a reproducible methodology using open-source tools and structured decision-making. ## The Three-Pillar Framework ### Pillar 1: Maximal Diagnostics Run every available diagnostic modality to build a complete molecular picture. Standard clinical panels miss non-obvious targets. **Minimum diagnostic stack (in priority order):** 1. **Genomics**: WGS + WES (tumor/normal paired) — somatic mutations, CNV, structural variants 2. **Transcriptomics**: Bulk RNA-seq + scRNA-seq (tumor + PBMCs) — gene expression, immune landscape, non-obvious targets 3. **Liquid biopsy**: ctDNA (tumor-informed, e.g. Signatera) + methylation-based (e.g. Northstar) — real-time monitoring 4. **Functional testing**: Organoid drug testing + mass response assays — empirical drug sensitivity 5. **Imaging**: Standard (CT/MRI) + novel PET tracers (68Ga-FAP, 68Ga-B7H3) — target validation 6. **Flow cytometry**: B/T cell subsets — immune status tracking …
Read the whole file at its exact version.
How to install
mdr add broomva/skills/founder-mode-oncology@sha256:558af549e6f26809The line at the top of this page pins the label git:20260628.9edbf07, which is what most people want. This one pins the sha256 fingerprint of the contents instead, so it survives a label being moved. Either way the exact version is written to mdr.lock, and mdr install downloads and checks those contents again, so it installs them exactly or stops with an error.
[](https://markdownregistry.com/a/art_32p7wke4ap56bwd6)
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Versions
The registry has recorded 1 version of this file, committed on Jun 28, 2026.
Audit of the latest version
- pass: Frontmatter block present
- pass: Frontmatter declares a name
- pass: Frontmatter declares a description
- pass: Size between 200 bytes and 200 KB (9848 bytes)
- pass: No zero-width or bidi control characters
- pass: No instruction hidden inside an HTML comment
- pass: No link to an exfiltration or paste host
- pass: No credential-shaped string
- pass: No instruction to send local credentials anywhere
- pass: No text hidden with inline styles
- pass: No prompt-injection phrasing
- pass: No curl or wget piped into a shell
- pass: No recursive delete of root, home or parent
- pass: No instruction to read or print local credentials
- pass: No base64 blob over 200 characters
- pass: No link to a raw IP address
- pass: No script tag
Source
broomva/skills · 5 stars · license MIT · pushed 2026-11-07 · branch main
API
GET https://markdownregistry.com/api/v1/artifacts/art_32p7wke4ap56bwd6 GET https://markdownregistry.com/api/v1/resolve?ref=broomva/skills/founder-mode-oncology GET https://markdownregistry.com/api/v1/blob/558af549e6f2680918d29d2e8271f1c278927a30d3fdbb85573b61eb97c7a57c
Your AI assistant does the legwork. You hear about the deals worth your word. Hand yours the standing instructions at modelranch.com and it joins the network that reads files like this one.
Guides: the SKILL.md format and its required fields · what to check before you install a skill · how to pin a skill to an exact version · where to find agent skills · keeping a team on the same skills · which agent file does what.