rfd4-proteina-nim SKILL.md skillA
rfd4-proteina-nim from nvidia/skills is an agent skill: a SKILL.md folder an AI agent loads when a task calls for it.
mdr add nvidia/skills/rfd4-proteina-nim@git:20261021.1ff5345Pins git:20261021.1ff5345 in mdr.lock. Pin the fingerprint instead.
- Audit grade
- A, 17 of 17 checks passed
- Kind
- SKILL.md skill
- Repository
- nvidia/skills
- Path
skills/bionemo-rfd4-proteina-nim/SKILL.md- Versions recorded
- 1
- Latest version
- git:20261021.1ff5345, committed Oct 21, 2026
- Size
- 10,543 bytes
- Repository stars
- 3,871
- License
- Apache-2.0
Run RFD4-Proteina NIM for joint protein structure and sequence design, conditioned generation, and reward-guided search using the NVIDIA hosted API or a self-hosted NIM. Not for the older RFdiffusion contigs API.
Collected from public GitHub. Every version is saved exactly as it was and never changes. Install it at an exact version with the mdr tool, and every file is checked before it reaches your agent. The main file is checked against the SHA-256 fingerprint recorded here, and the others against the fingerprints GitHub keeps for its source commit. The automatic checks below grade the latest version, and the same checks always give the same file the same grade.
What the file says
# RFD4-Proteina NIM Generate protein structures and sequences through the released [RFD4-Proteina NIM](https://build.nvidia.com/ipd/rfd4-proteina). This skill covers conditioned protein and small-molecule binders, motif and enzyme scaffolding, antibody/CDR design, partial diffusion, inverse folding, and reward-guided beam search. Use [science](references/science.md) for interpretation. ## Prerequisites Use Python 3.10 or newer; the client uses only the standard library. Hosted inference requires a key obtained from the product page, set as `NVIDIA_API_KEY` (`NGC_API_KEY` is accepted as a fallback). Supply the key through the user's secret mechanism, not a prompt or command-line argument. Offline preparation and saved-response extraction need no credentials. For an existing local NIM, use its base URL. Starting a new container also requires Docker, NVIDIA Container Toolkit, a supported GPU/driver, and NGC access; read [deployment](references/deployment.md) only when deployment is needed. ## Instructions 1. **Choose the requested destination.** Use `hosted` for NVIDIA's API or `local` for a user-operated NIM. Do not switch destinations after an error. …
Read the whole file at its exact version.
How to install
mdr add nvidia/skills/rfd4-proteina-nim@sha256:277eebc9de6b180aThe line at the top of this page pins the label git:20261021.1ff5345, which is what most people want. This one pins the sha256 fingerprint of the contents instead, so it survives a label being moved. Either way the exact version is written to mdr.lock, and mdr install downloads and checks those contents again, so it installs them exactly or stops with an error.
[](https://markdownregistry.com/a/art_gwg7x7d5csqqpwii)
3 badge image fetches in 30 days. What the badge shows.
Versions
The registry has recorded 1 version of this file, committed on Oct 21, 2026.
Audit of the latest version
- pass: Frontmatter block present
- pass: Frontmatter declares a name
- pass: Frontmatter declares a description
- pass: Size between 200 bytes and 200 KB (10543 bytes)
- pass: No zero-width or bidi control characters
- pass: No instruction hidden inside an HTML comment
- pass: No link to an exfiltration or paste host
- pass: No credential-shaped string
- pass: No instruction to send local credentials anywhere
- pass: No text hidden with inline styles
- pass: No prompt-injection phrasing
- pass: No curl or wget piped into a shell
- pass: No recursive delete of root, home or parent
- pass: No instruction to read or print local credentials
- pass: No base64 blob over 200 characters
- pass: No link to a raw IP address
- pass: No script tag
Source
nvidia/skills · 3,871 stars · license Apache-2.0 · pushed 2026-11-05 · branch main
API
GET https://markdownregistry.com/api/v1/artifacts/art_gwg7x7d5csqqpwii GET https://markdownregistry.com/api/v1/resolve?ref=nvidia/skills/rfd4-proteina-nim GET https://markdownregistry.com/api/v1/blob/277eebc9de6b180ac0b732ab2d892e38013151f91ba322f740b949fb7725e0bd
Your AI assistant does the legwork. You hear about the deals worth your word. Hand yours the standing instructions at modelranch.com and it joins the network that reads files like this one.
Guides: the SKILL.md format and its required fields · what to check before you install a skill · how to pin a skill to an exact version · where to find agent skills · keeping a team on the same skills · which agent file does what.