Home / jmschrei / tangermeme · GitHub

tangermeme SKILL.md skillA

tangermeme from jmschrei/tangermeme is an agent skill: a SKILL.md folder an AI agent loads when a task calls for it.

Install it, pinned
mdr add jmschrei/tangermeme/tangermeme@git:20261019.f1464b4

Pins git:20261019.f1464b4 in mdr.lock. Pin the fingerprint instead.

Audit grade
A, 17 of 17 checks passed
Kind
SKILL.md skill
Repository
jmschrei/tangermeme
Path
tangermeme/_skills/data/SKILL.md
Versions recorded
9
Latest version
git:20261019.f1464b4, committed Oct 19, 2026
First version recorded
Sep 10, 2026
Size
4,725 bytes
Repository stars
332
License
MIT

Use for any task involving the tangermeme library — post-training analysis of genomic sequence-to-function (S2F) deep learning models. Triggers on predictions, DeepLIFT/SHAP attributions, saliency, PISA, dependency maps, marginalization/ablation/spacing of motifs, saturation mutagenesis (ISM), variant effect scoring, sequence design, seqlet calling, motif annotation, loading loci/FASTA/bigWig/MEME/VCF, GC-matched backgrounds, packed sequences, or wrapping a PyTorch genomic model for these…

Collected from public GitHub. Every version is saved exactly as it was and never changes. Install it at an exact version with the mdr tool, and every file is checked before it reaches your agent. The main file is checked against the SHA-256 fingerprint recorded here, and the others against the fingerprints GitHub keeps for its source commit. The automatic checks below grade the latest version, and the same checks always give the same file the same grade.

What the file says

# tangermeme

Post-training analysis of any PyTorch sequence model: batched prediction,
attribution, perturbation experiments, sequence design, on raw outputs with
no distance baked in. This file routes; the reference files hold the
signatures, defaults and silent failures. Read the file for the task before
writing code: several defaults select the wrong output, return a variable
number of objects, or run zero iterations without a word.

## Task to reference file

| task | read |
|---|---|
| attribution via **DeepLIFT/SHAP**: which bases drive this prediction, logos, hypothetical scores for CWMs, references, memory | `references/deep_lift_shap.md` |
| a **convergence delta warning**, a transformer, attention pooling, a functional softmax or product, a custom module, "are these attributions correct" | `references/deep_lift_shap-unhooked-ops.md` and `scripts/audit_deeplift.py` |
| **ISM / saturation mutagenesis**, `fast=True` | `references/saturation_mutagenesis.md` |
| **saliency** (input x gradient, one backward pass) and **dependency maps** (epistasis, motif-flank interactions) | `references/dependency_map.md` |
…

Read the whole file at its exact version.

How to install

The exact contents, by fingerprint
mdr add jmschrei/tangermeme/tangermeme@sha256:5353746af945ce03

The line at the top of this page pins the label git:20261019.f1464b4, which is what most people want. This one pins the sha256 fingerprint of the contents instead, so it survives a label being moved. Either way the exact version is written to mdr.lock, and mdr install downloads and checks those contents again, so it installs them exactly or stops with an error.

Badge

mdr badge

[![mdr](https://markdownregistry.com/badge/art_n6xkexqpmmwwsfda.svg)](https://markdownregistry.com/a/art_n6xkexqpmmwwsfda)

3 badge image fetches in 30 days. What the badge shows.

Versions

The registry has recorded 9 versions of this file, between Sep 10, 2026 and Oct 19, 2026, about one every 5 days.

versioncommittedcommitsizeaudit
git:20261019.f1464b4 latest2026-10-19 f1464b4 4,725 BA view · diff
git:20261019.4daf2942026-10-19 4daf294 7,922 BA view · diff
git:20261018.8dd06402026-10-18 8dd0640 6,899 BA view · diff
git:20261012.952250e2026-10-12 952250e 6,450 BA view · diff
git:20261011.6255e472026-10-11 6255e47 6,412 BA view · diff
git:20261002.cc9c3aa2026-10-02 cc9c3aa 6,347 BA view · diff
git:20260929.c62a8502026-09-29 c62a850 6,323 BA view · diff
git:20260922.ee23fdf2026-09-22 ee23fdf 6,233 BA view · diff
git:20260910.78aae662026-09-10 78aae66 6,094 BA view

Audit of the latest version

A  17 of 17 checks passed. Fixed automatic checks with no AI involved, so the same checks give the same answer every run.
  • pass: Frontmatter block present
  • pass: Frontmatter declares a name
  • pass: Frontmatter declares a description
  • pass: Size between 200 bytes and 200 KB (4725 bytes)
  • pass: No zero-width or bidi control characters
  • pass: No instruction hidden inside an HTML comment
  • pass: No link to an exfiltration or paste host
  • pass: No credential-shaped string
  • pass: No instruction to send local credentials anywhere
  • pass: No text hidden with inline styles
  • pass: No prompt-injection phrasing
  • pass: No curl or wget piped into a shell
  • pass: No recursive delete of root, home or parent
  • pass: No instruction to read or print local credentials
  • pass: No base64 blob over 200 characters
  • pass: No link to a raw IP address
  • pass: No script tag

Source

GitHub

jmschrei/tangermeme · 332 stars · license MIT · pushed 2026-10-20 · branch main

API

GET https://markdownregistry.com/api/v1/artifacts/art_n6xkexqpmmwwsfda
GET https://markdownregistry.com/api/v1/resolve?ref=jmschrei/tangermeme/tangermeme
GET https://markdownregistry.com/api/v1/blob/5353746af945ce03936255f2e7e7ad2b41b201fff31b8daa909156250f306764

Your AI assistant does the legwork. You hear about the deals worth your word. Hand yours the standing instructions at modelranch.com and it joins the network that reads files like this one.

Guides: the SKILL.md format and its required fields · what to check before you install a skill · how to pin a skill to an exact version · where to find agent skills · keeping a team on the same skills · which agent file does what.

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