agents365-ai/365-skills · plugins/target-prioritization/skills/target-prioritization/SKILL.md
target-prioritization skillA
Prioritize drug targets from a ranked gene list (e.g., scRNA-seq DE output) by orchestrating parallel API queries against UniProt, OpenTargets (with integrated DepMap CRISPR essentiality + gnomAD constraint), PubMed, the Human Protein Atlas (HPA), and ChEMBL tool compounds, then re-ranking by a composite score combining protein localization, druggability, disease genetics, tissue specificity (safety), focus-cell-type expression, CRISPR essentiality, LoF safety constraint, and research maturity.
Latest version
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Versions
| version | committed | commit | size | audit | |
|---|---|---|---|---|---|
| git:20260904.f37f318 latest | 2026-09-04 | f37f318 | 10,894 B | A | view · diff |
| git:20260520.c87adb4 | 2026-05-20 | c87adb4 | 9,287 B | A | view · diff |
| git:20260520.954ae40 | 2026-05-20 | 954ae40 | 8,049 B | A | view · diff |
| git:20260520.59814e1 | 2026-05-20 | 59814e1 | 7,178 B | A | view · diff |
| git:20260519.9983505 | 2026-05-19 | 9983505 | 7,744 B | A | view |
Audit of the latest version
A 17 of 17 checks passed. Deterministic, no model, same answer every run.
- pass: Frontmatter block present
- pass: Frontmatter declares a name
- pass: Frontmatter declares a description
- pass: Size between 200 bytes and 200 KB (10894 bytes)
- pass: No zero-width or bidi control characters
- pass: No instruction hidden inside an HTML comment
- pass: No link to an exfiltration or paste host
- pass: No credential-shaped string
- pass: No instruction to send local credentials anywhere
- pass: No text hidden with inline styles
- pass: No prompt-injection phrasing
- pass: No curl or wget piped into a shell
- pass: No recursive delete of root, home or parent
- pass: No instruction to read or print local credentials
- pass: No base64 blob over 200 characters
- pass: No link to a raw IP address
- pass: No script tag
Source
GitHub
agents365-ai/365-skills · 38 stars · license none · pushed 2026-09-04 · branch main
API
GET https://markdownregistry.com/api/v1/artifacts/art_vatigt6kxvltdosg GET https://markdownregistry.com/api/v1/resolve?ref=agents365-ai/365-skills/target-prioritization GET https://markdownregistry.com/api/v1/blob/a49ceee84f5ad5072eaaa21b914d908a0ee217476f6f383ce4c958e937f0b9da