openfold2-nim SKILL.md skillA

This file is byte-identical to the first copy the registry indexed, one of 3 indexed copies. Same content hash, so the same checks give both the same grade.

openfold2-nim from nvidia-bionemo/bionemo-agent-toolkit is an agent skill: a SKILL.md folder an AI agent loads when a task calls for it.

Install it, pinned
mdr add nvidia-bionemo/bionemo-agent-toolkit/openfold2-nim@git:20260919.2c853ab

Pins git:20260919.2c853ab in mdr.lock. Pin the fingerprint instead.

Audit grade
A, 17 of 17 checks passed
Kind
SKILL.md skill
Repository
nvidia-bionemo/bionemo-agent-toolkit
Path
nim-skills/openfold2-nim/SKILL.md
Versions recorded
3
Latest version
git:20260919.2c853ab, committed Sep 19, 2026
First version recorded
Jun 23, 2026
Size
7,208 bytes
Repository stars
503
License
a license file GitHub does not identify

Use this skill for OpenFold2, NVIDIA's BioNeMo NIM microservice for monomer protein structure prediction. Invoke whenever the user mentions OpenFold2, AlphaFold2-like monomer folding, protein sequence-to-structure prediction, A3M MSAs, mmCIF templates, hosted NVIDIA API calls, or local Docker deployment.

Collected from public GitHub. Every version is saved exactly as it was and never changes. Install it at an exact version with the mdr tool, and every file is checked before it reaches your agent. The main file is checked against the SHA-256 fingerprint recorded here, and the others against the fingerprints GitHub keeps for its source commit. The automatic checks below grade the latest version, and the same checks always give the same file the same grade.

What the file says

# OpenFold2 NIM

Predict a single protein-chain structure from an amino-acid sequence, with
optional A3M multiple sequence alignments and mmCIF templates. Use this
guide for basic hosted/local NIM use; load supplemental files only when
the task needs deeper context:

- `references/api.md`: exact endpoints, schemas, Docker flags, response fields.
- `references/science.md`: model scope, strengths, limitations, and handoffs.
- `references/parameters.md`: MSA, template, model-selection, and relax effects.
- `references/validation.md`: artifact and scientific sanity checks.
- `references/examples.md`: compact hosted/local payload patterns.

## Choose Mode

Ask only when context is unclear:

> Hosted NVIDIA API or local Docker NIM?

- Hosted URL: `https://health.api.nvidia.com/v1/biology/openfold/openfold2/predict-structure-from-msa-and-template`
- Local URL: `http://localhost:8000/biology/openfold/openfold2/predict-structure-from-msa-and-template`
- Local readiness: `http://localhost:8000/v1/health/ready`

Mode difference: hosted and local use the same prediction path except local
does not include `/v1/`. Hosted requests use `Authorization: Bearer
…

Read the whole file at its exact version.

How to install

The exact contents, by fingerprint
mdr add nvidia-bionemo/bionemo-agent-toolkit/openfold2-nim@sha256:b64ca4615dd0c920

The line at the top of this page pins the label git:20260919.2c853ab, which is what most people want. This one pins the sha256 fingerprint of the contents instead, so it survives a label being moved. Either way the exact version is written to mdr.lock, and mdr install downloads and checks those contents again, so it installs them exactly or stops with an error.

Badge

mdr badge

[![mdr](https://markdownregistry.com/badge/art_4zp2d672serslj2t.svg)](https://markdownregistry.com/a/art_4zp2d672serslj2t)

3 badge image fetches in 30 days. What the badge shows.

Versions

The registry has recorded 3 versions of this file, between Jun 23, 2026 and Sep 19, 2026, about one every 44 days.

versioncommittedcommitsizeaudit
git:20260919.2c853ab latest2026-09-19 2c853ab 7,208 BA view · diff
git:20260812.47315cc2026-08-12 47315cc 7,213 BA view · diff
git:20260623.4e8fda72026-06-23 4e8fda7 7,670 BA view

Audit of the latest version

A  17 of 17 checks passed. Fixed automatic checks with no AI involved, so the same checks give the same answer every run.
  • pass: Frontmatter block present
  • pass: Frontmatter declares a name
  • pass: Frontmatter declares a description
  • pass: Size between 200 bytes and 200 KB (7208 bytes)
  • pass: No zero-width or bidi control characters
  • pass: No instruction hidden inside an HTML comment
  • pass: No link to an exfiltration or paste host
  • pass: No credential-shaped string
  • pass: No instruction to send local credentials anywhere
  • pass: No text hidden with inline styles
  • pass: No prompt-injection phrasing
  • pass: No curl or wget piped into a shell
  • pass: No recursive delete of root, home or parent
  • pass: No instruction to read or print local credentials
  • pass: No base64 blob over 200 characters
  • pass: No link to a raw IP address
  • pass: No script tag

Source

GitHub

nvidia-bionemo/bionemo-agent-toolkit · 503 stars · license a license file GitHub does not identify · pushed 2026-11-05 · branch main

API

GET https://markdownregistry.com/api/v1/artifacts/art_4zp2d672serslj2t
GET https://markdownregistry.com/api/v1/resolve?ref=nvidia-bionemo/bionemo-agent-toolkit/openfold2-nim
GET https://markdownregistry.com/api/v1/blob/b64ca4615dd0c920ed742236f2de922c9f94dba4e4d3a6413a5b24b292877382

Your AI assistant does the legwork. You hear about the deals worth your word. Hand yours the standing instructions at modelranch.com and it joins the network that reads files like this one.

Guides: the SKILL.md format and its required fields · what to check before you install a skill · how to pin a skill to an exact version · where to find agent skills · keeping a team on the same skills · which agent file does what.

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Every file in nvidia-bionemo/bionemo-agent-toolkit

Other files named openfold2-nim

openfold2-nim SKILL.md skill
nvidia/skills · skills/bionemo-openfold2-nim/SKILL.md · Use this skill for OpenFold2, NVIDIA's BioNeMo NIM microservice for monomer protein structure prediction. Invoke…
git:20260923.d232a17 · audit A · 3,871 stars
openfold2-nim SKILL.md skill
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git:20260919.2c853ab · audit A · 503 stars

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