depmap SKILL.md skillA
depmap from marielynneblock/arcanum-artifex is an agent skill: a SKILL.md folder an AI agent loads when a task calls for it.
mdr add marielynneblock/arcanum-artifex/depmap@git:20260710.0115f49Pins git:20260710.0115f49 in mdr.lock. Pin the fingerprint instead.
- Audit grade
- A, 17 of 17 checks passed
- Kind
- SKILL.md skill
- Repository
- marielynneblock/arcanum-artifex
- Path
skills/scientific/depmap/SKILL.md- Versions recorded
- 4
- Latest version
- git:20260710.0115f49, committed Jul 10, 2026
- First version recorded
- Apr 6, 2026
- Size
- 11,277 bytes
- Repository stars
- 4
- License
- none declared
Query the Cancer Dependency Map (DepMap) for cancer cell line gene dependency scores (CRISPR Chronos), drug sensitivity data, and gene effect profiles. Use for identifying cancer-specific vulnerabilities, synthetic lethal interactions, and validating oncology drug targets.
Collected from public GitHub. Every version is saved exactly as it was and never changes. Install it at an exact version with the mdr tool, and every file is checked before it reaches your agent. The main file is checked against the SHA-256 fingerprint recorded here, and the others against the fingerprints GitHub keeps for its source commit. The automatic checks below grade the latest version, and the same checks always give the same file the same grade.
What the file says
# DepMap — Cancer Dependency Map ## Overview The Cancer Dependency Map (DepMap) project, run by the Broad Institute, systematically characterises genetic dependencies across hundreds of cancer cell lines using genome-wide CRISPR knockout screens (DepMap CRISPR), RNA interference (RNAi), and compound sensitivity assays (PRISM). DepMap data is essential for: - Identifying which genes are essential for specific cancer types - Finding cancer-selective dependencies (therapeutic targets) - Validating oncology drug targets - Discovering synthetic lethal interactions **Key resources:** - DepMap Portal: https://depmap.org/portal/ - DepMap data downloads: https://depmap.org/portal/download/all/ - Python package: `depmap` (or access via API/downloads) - API: https://depmap.org/portal/api/ ## When to Use This Skill Use DepMap when: - **Target validation**: Is a gene essential for survival in cancer cell lines with a specific mutation (e.g., KRAS-mutant)? - **Biomarker discovery**: What genomic features predict sensitivity to knockout of a gene? - **Synthetic lethality**: Find genes that are selectively essential when another gene is mutated/deleted …
Read the whole file at its exact version.
How to install
mdr add marielynneblock/arcanum-artifex/depmap@sha256:e2c049b88443cdaaThe line at the top of this page pins the label git:20260710.0115f49, which is what most people want. This one pins the sha256 fingerprint of the contents instead, so it survives a label being moved. Either way the exact version is written to mdr.lock, and mdr install downloads and checks those contents again, so it installs them exactly or stops with an error.
[](https://markdownregistry.com/a/art_6zsqj46b5gvk4egd)
4 badge image fetches in 30 days. What the badge shows.
Versions
The registry has recorded 4 versions of this file, between Apr 6, 2026 and Jul 10, 2026, about one every 32 days.
| version | committed | commit | size | audit | |
|---|---|---|---|---|---|
| git:20260710.0115f49 latest | 2026-07-10 | 0115f49 | 11,277 B | A | view · diff |
| git:20260710.ffb3400 | 2026-07-10 | ffb3400 | 11,277 B | A | view · diff |
| git:20260515.b861afb | 2026-05-15 | b861afb | 11,277 B | A | view · diff |
| git:20260406.05dff34 | 2026-04-06 | 05dff34 | 11,277 B | A | view |
Audit of the latest version
- pass: Frontmatter block present
- pass: Frontmatter declares a name
- pass: Frontmatter declares a description
- pass: Size between 200 bytes and 200 KB (11277 bytes)
- pass: No zero-width or bidi control characters
- pass: No instruction hidden inside an HTML comment
- pass: No link to an exfiltration or paste host
- pass: No credential-shaped string
- pass: No instruction to send local credentials anywhere
- pass: No text hidden with inline styles
- pass: No prompt-injection phrasing
- pass: No curl or wget piped into a shell
- pass: No recursive delete of root, home or parent
- pass: No instruction to read or print local credentials
- pass: No base64 blob over 200 characters
- pass: No link to a raw IP address
- pass: No script tag
Source
marielynneblock/arcanum-artifex · 4 stars · license none declared · pushed 2026-09-19 · branch main
API
GET https://markdownregistry.com/api/v1/artifacts/art_6zsqj46b5gvk4egd GET https://markdownregistry.com/api/v1/resolve?ref=marielynneblock/arcanum-artifex/depmap GET https://markdownregistry.com/api/v1/blob/e2c049b88443cdaaf0dc7914763e8c89d948f9eb60968bafe9b3a8ef440f3d0d
Your AI assistant does the legwork. You hear about the deals worth your word. Hand yours the standing instructions at modelranch.com and it joins the network that reads files like this one.
Guides: the SKILL.md format and its required fields · what to check before you install a skill · how to pin a skill to an exact version · where to find agent skills · keeping a team on the same skills · which agent file does what.
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