alphagenome-single-variant-analysis SKILL.md skillA
alphagenome-single-variant-analysis from fridrichmethod/awesome-skills is an agent skill: a SKILL.md folder an AI agent loads when a task calls for it.
mdr add fridrichmethod/awesome-skills/alphagenome-single-variant-analysis@git:20260913.5d8c8f0Pins git:20260913.5d8c8f0 in mdr.lock. Pin the fingerprint instead.
- Audit grade
- A, 17 of 17 checks passed
- Kind
- SKILL.md skill
- Repository
- fridrichmethod/awesome-skills
- Path
skills/alphagenome_single_variant_analysis/SKILL.md- Versions recorded
- 3
- Latest version
- git:20260913.5d8c8f0, committed Sep 13, 2026
- First version recorded
- Jun 10, 2026
- Size
- 11,961 bytes
- Repository stars
- 15
- License
- a license file GitHub does not identify
Analyzes genetic variant effects on gene expression (RNA-seq), chromatin accessibility (DNASE), histone marks (ChIP), and transcription factors using the AlphaGenome API. Use when the user asks about non-coding variant effects, pathogenicity, clinical significance, disease associations, functional effects, gene expression changes, splicing disruption, or regulatory effects in promoters and enhancers. Also use for resolving biological terms to tissue/cell-type ontologies (UBERON/CL) or…
Collected from public GitHub. Every version is saved exactly as it was and never changes. Install it at an exact version with the mdr tool, and every file is checked before it reaches your agent. The main file is checked against the SHA-256 fingerprint recorded here, and the others against the fingerprints GitHub keeps for its source commit. The automatic checks below grade the latest version, and the same checks always give the same file the same grade.
What the file says
# Variant Analysis using AlphaGenome
## Prerequisites
1. **`uv`**: Read the `uv` skill and follow its Setup instructions to ensure
`uv` is installed and on PATH.
2. **User Notification**: If
.licenses/alphagenome_single_variant_analysis_LICENSE.txt does not already
exist in the workspace root directory then (1) prominently notify the user
to check the terms at https://deepmind.google.com/science/alphagenome/, then
(2) create the file recording the notification text and timestamp.
3. **`.env` file**: Make sure the `.env` file exists in your home directory.
Create one if it does not exist.
4. **`ALPHAGENOME_API_KEY`**: This skill requires an API key to function.
You can register for a key at https://deepmind.google.com/science/alphagenome/.
You **MUST** use the safe credentials protocol in the `credentials` skill to
check for and request this key if this skill looks relevant to the user's request.
5. **`ALPHAGENOME_GTF_PATH` (Optional)**: Accelerate gene/transcript lookup by
pointing to a local copy of the GTF feather file instead of downloading from
GCS:
```bash
…Read the whole file at its exact version.
How to install
mdr add fridrichmethod/awesome-skills/alphagenome-single-variant-analysis@sha256:276477c29ba56e2eThe line at the top of this page pins the label git:20260913.5d8c8f0, which is what most people want. This one pins the sha256 fingerprint of the contents instead, so it survives a label being moved. Either way the exact version is written to mdr.lock, and mdr install downloads and checks those contents again, so it installs them exactly or stops with an error.
[](https://markdownregistry.com/a/art_a7qs7tshcun5rxao)
1 badge image fetches in 30 days. What the badge shows.
Versions
The registry has recorded 3 versions of this file, between Jun 10, 2026 and Sep 13, 2026, about one every 48 days. Its first recorded version is graded B and its latest A.
| version | committed | commit | size | audit | |
|---|---|---|---|---|---|
| git:20260913.5d8c8f0 latest | 2026-09-13 | 5d8c8f0 | 11,961 B | A | view · diff |
| git:20260705.1380472 | 2026-07-05 | 1380472 | 11,674 B | A | view · diff |
| git:20260610.57ad09c | 2026-06-10 | 57ad09c | 12,396 B | B | view |
Audit of the latest version
- pass: Frontmatter block present
- pass: Frontmatter declares a name
- pass: Frontmatter declares a description
- pass: Size between 200 bytes and 200 KB (11961 bytes)
- pass: No zero-width or bidi control characters
- pass: No instruction hidden inside an HTML comment
- pass: No link to an exfiltration or paste host
- pass: No credential-shaped string
- pass: No instruction to send local credentials anywhere
- pass: No text hidden with inline styles
- pass: No prompt-injection phrasing
- pass: No curl or wget piped into a shell
- pass: No recursive delete of root, home or parent
- pass: No instruction to read or print local credentials
- pass: No base64 blob over 200 characters
- pass: No link to a raw IP address
- pass: No script tag
Source
fridrichmethod/awesome-skills · 15 stars · license a license file GitHub does not identify · pushed 2026-10-18 · branch main
API
GET https://markdownregistry.com/api/v1/artifacts/art_a7qs7tshcun5rxao GET https://markdownregistry.com/api/v1/resolve?ref=fridrichmethod/awesome-skills/alphagenome-single-variant-analysis GET https://markdownregistry.com/api/v1/blob/276477c29ba56e2e4ddf7152930ab64ef6c90e0e483cffbe3adee0d4075f9e68
Your AI assistant does the legwork. You hear about the deals worth your word. Hand yours the standing instructions at modelranch.com and it joins the network that reads files like this one.
Guides: the SKILL.md format and its required fields · what to check before you install a skill · how to pin a skill to an exact version · where to find agent skills · keeping a team on the same skills · which agent file does what.