method-genome-build SKILL.md skillA
method-genome-build from sajor2000/methodsmith is an agent skill: a SKILL.md folder an AI agent loads when a task calls for it.
mdr add sajor2000/methodsmith/method-genome-build@git:20261016.73e5a37Pins git:20261016.73e5a37 in mdr.lock. Pin the fingerprint instead.
- Audit grade
- A, 17 of 17 checks passed
- Kind
- SKILL.md skill
- Repository
- sajor2000/methodsmith
- Path
plugins/methodsmith/skills/method-genome-build/SKILL.md- Versions recorded
- 1
- Latest version
- git:20261016.73e5a37, committed Oct 16, 2026
- Size
- 6,365 bytes
- Repository stars
- 3
- License
- MIT
Pins genome build, annotation release, contig naming, and liftover for genomics data. Use when the user mentions GRCh37/38, hg19/hg38, T2T, GENCODE/Ensembl versions, or liftover.
Collected from public GitHub. Every version is saved exactly as it was and never changes. Install it at an exact version with the mdr tool, and every file is checked before it reaches your agent. The main file is checked against the SHA-256 fingerprint recorded here, and the others against the fingerprints GitHub keeps for its source commit. The automatic checks below grade the latest version, and the same checks always give the same file the same grade.
What the file says
# Genome Build Traceability ## Skill Value - **Problem it solves:** Genomics analyses silently break when build, annotation, or contig conventions drift. - **Use when:** The user mentions genome build, GRCh37/38, hg19/hg38, annotation versions, liftover, or VCF/BAM compatibility. - **Output:** Genome-build decision record with reference sources and downstream constraints. - **Ask only if:** Only when build, annotation source, or target assay cannot be inferred. - **Do not do:** Do not run variant analysis or liftover without explicit workflow scope. - **Interaction:** Check repo/config/chat evidence first. Ask one decision-changing question at a time; use the current harness's blocking question UI when available, otherwise present numbered choices and wait. Pins the reference genome and annotation versions used in a bioinformatics study, and audits every output for build consistency. Without this, a paper claiming "we used GRCh38" can have outputs silently aligned to GRCh37 because a single tool defaulted to its bundled reference. ## When this skill activates - Start of a new bioinformatics study (declare the build) - After a reference update (re-declare and audit) …
Read the whole file at its exact version.
How to install
mdr add sajor2000/methodsmith/method-genome-build@sha256:2433637eb3b21bbfThe line at the top of this page pins the label git:20261016.73e5a37, which is what most people want. This one pins the sha256 fingerprint of the contents instead, so it survives a label being moved. Either way the exact version is written to mdr.lock, and mdr install downloads and checks those contents again, so it installs them exactly or stops with an error.
[](https://markdownregistry.com/a/art_bhc3fn74roi236vs)
1 badge image fetches in 30 days. What the badge shows.
Versions
The registry has recorded 1 version of this file, committed on Oct 16, 2026.
Audit of the latest version
- pass: Frontmatter block present
- pass: Frontmatter declares a name
- pass: Frontmatter declares a description
- pass: Size between 200 bytes and 200 KB (6365 bytes)
- pass: No zero-width or bidi control characters
- pass: No instruction hidden inside an HTML comment
- pass: No link to an exfiltration or paste host
- pass: No credential-shaped string
- pass: No instruction to send local credentials anywhere
- pass: No text hidden with inline styles
- pass: No prompt-injection phrasing
- pass: No curl or wget piped into a shell
- pass: No recursive delete of root, home or parent
- pass: No instruction to read or print local credentials
- pass: No base64 blob over 200 characters
- pass: No link to a raw IP address
- pass: No script tag
Source
sajor2000/methodsmith · 3 stars · license MIT · pushed 2026-10-19 · branch main
API
GET https://markdownregistry.com/api/v1/artifacts/art_bhc3fn74roi236vs GET https://markdownregistry.com/api/v1/resolve?ref=sajor2000/methodsmith/method-genome-build GET https://markdownregistry.com/api/v1/blob/2433637eb3b21bbf5893a3c378691e7832a9ad179b2c96e7bba17049b82a1ebc
Your AI assistant does the legwork. You hear about the deals worth your word. Hand yours the standing instructions at modelranch.com and it joins the network that reads files like this one.
Guides: the SKILL.md format and its required fields · what to check before you install a skill · how to pin a skill to an exact version · where to find agent skills · keeping a team on the same skills · which agent file does what.