alphagenome-variant-impact-score SKILL.md skillA
alphagenome-variant-impact-score from fridrichmethod/awesome-skills is an agent skill: a SKILL.md folder an AI agent loads when a task calls for it.
mdr add fridrichmethod/awesome-skills/alphagenome-variant-impact-score@git:20260913.5d8c8f0Pins git:20260913.5d8c8f0 in mdr.lock. Pin the fingerprint instead.
- Audit grade
- A, 17 of 17 checks passed
- Kind
- SKILL.md skill
- Repository
- fridrichmethod/awesome-skills
- Path
skills/alphagenome_variant_impact_score/SKILL.md- Versions recorded
- 1
- Latest version
- git:20260913.5d8c8f0, committed Sep 13, 2026
- Size
- 16,704 bytes
- Repository stars
- 15
- License
- a license file GitHub does not identify
Score, annotate, and analyze the functional impact of genetic variants using AlphaGenome Variant Impact (AVI) scores. Query variants in chr:pos:ref>alt format, annotate VCF/tabular callsets, perform saturation mutagenesis window scans (1-based closed chr:start-end), and extract GENCODE v46 GTF gene/exon/junction coordinates all via the AlphaGenome Atlas API.
Collected from public GitHub. Every version is saved exactly as it was and never changes. Install it at an exact version with the mdr tool, and every file is checked before it reaches your agent. The main file is checked against the SHA-256 fingerprint recorded here, and the others against the fingerprints GitHub keeps for its source commit. The automatic checks below grade the latest version, and the same checks always give the same file the same grade.
What the file says
# AlphaGenome Variant Impact (AVI) Analysis Score and prioritize genetic variants using AlphaGenome Variant Impact (AVI) models via `scripts/alphagenome_atlas_avi.py`. > [!IMPORTANT] **Research Use Only & Clinical Safety Rules**: The AlphaGenome > AVI Skill and the underlying AlphaGenome model/Atlas are **strictly research > tools**. Access to outputs requires an AlphaGenome API key subject to terms of > service prohibiting clinical use. > > 1. **No Medical Advice or Clinical Diagnosis**: You **MUST NOT** provide > medical advice, clinical diagnoses, disease management strategies, or > treatment recommendations based on outputs from this skill or the > AlphaGenome Atlas. > 2. **Strict Molecular & Functional Framing**: A high AVI score reflects > **predicted molecular/functional impact** (e.g., disruption of splicing, > alteration of transcription factor binding, chromatin accessibility > changes, or coding consequences). Frame all findings in terms of molecular > mechanisms and biological annotations—never as clinical diagnoses or > medical conclusions. > 3. **No Diagnostic Leaps**: Never extrapolate high functional impact to …
Read the whole file at its exact version.
How to install
mdr add fridrichmethod/awesome-skills/alphagenome-variant-impact-score@sha256:eeb02a0c66918acbThe line at the top of this page pins the label git:20260913.5d8c8f0, which is what most people want. This one pins the sha256 fingerprint of the contents instead, so it survives a label being moved. Either way the exact version is written to mdr.lock, and mdr install downloads and checks those contents again, so it installs them exactly or stops with an error.
[](https://markdownregistry.com/a/art_j6pn4tbheuwphtbe)
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Versions
The registry has recorded 1 version of this file, committed on Sep 13, 2026.
Audit of the latest version
- pass: Frontmatter block present
- pass: Frontmatter declares a name
- pass: Frontmatter declares a description
- pass: Size between 200 bytes and 200 KB (16704 bytes)
- pass: No zero-width or bidi control characters
- pass: No instruction hidden inside an HTML comment
- pass: No link to an exfiltration or paste host
- pass: No credential-shaped string
- pass: No instruction to send local credentials anywhere
- pass: No text hidden with inline styles
- pass: No prompt-injection phrasing
- pass: No curl or wget piped into a shell
- pass: No recursive delete of root, home or parent
- pass: No instruction to read or print local credentials
- pass: No base64 blob over 200 characters
- pass: No link to a raw IP address
- pass: No script tag
Source
fridrichmethod/awesome-skills · 15 stars · license a license file GitHub does not identify · pushed 2026-10-18 · branch main
API
GET https://markdownregistry.com/api/v1/artifacts/art_j6pn4tbheuwphtbe GET https://markdownregistry.com/api/v1/resolve?ref=fridrichmethod/awesome-skills/alphagenome-variant-impact-score GET https://markdownregistry.com/api/v1/blob/eeb02a0c66918acb098240bace7a726cec6bbd2a7eb067ff91d7a903b857f5ce
Your AI assistant does the legwork. You hear about the deals worth your word. Hand yours the standing instructions at modelranch.com and it joins the network that reads files like this one.
Guides: the SKILL.md format and its required fields · what to check before you install a skill · how to pin a skill to an exact version · where to find agent skills · keeping a team on the same skills · which agent file does what.