bio-chipseq-allele-specific-binding SKILL.md skillA
bio-chipseq-allele-specific-binding from fridrichmethod/awesome-skills is an agent skill: a SKILL.md folder an AI agent loads when a task calls for it.
mdr add fridrichmethod/awesome-skills/bio-chipseq-allele-specific-binding@git:20260719.44d7640Pins git:20260719.44d7640 in mdr.lock. Pin the fingerprint instead.
- Audit grade
- A, 17 of 17 checks passed
- Kind
- SKILL.md skill
- Repository
- fridrichmethod/awesome-skills
- Path
skills/allele-specific-binding/SKILL.md- Versions recorded
- 3
- Latest version
- git:20260719.44d7640, committed Jul 19, 2026
- First version recorded
- May 17, 2026
- Size
- 15,447 bytes
- Repository stars
- 15
- License
- a license file GitHub does not identify
Detects allele-specific transcription factor or histone modification binding from heterozygous-variant ChIP-seq using WASP (reference-bias filter; mandatory upstream), RASQUAL (joint QTL + bias-corrected testing), BaalChIP (Bayesian beta-binomial with copy-number-aware overdispersion), and AlleleSeq (personalized diploid genome). Handles imprinted-locus awareness, X-inactivation artifacts, cancer copy-number imbalance, and integration with downstream caQTL / bQTL mapping. Use when identifying…
Collected from public GitHub. Every version is saved exactly as it was and never changes. Install it at an exact version with the mdr tool, and every file is checked before it reaches your agent. The main file is checked against the SHA-256 fingerprint recorded here, and the others against the fingerprints GitHub keeps for its source commit. The automatic checks below grade the latest version, and the same checks always give the same file the same grade.
What the file says
## Version Compatibility Reference examples tested with: WASP 0.3.4+, RASQUAL 1.1+, BaalChIP 1.30+ (Bioconductor), AlleleSeq 2.0+, samtools 1.19+, bcftools 1.19+, GATK 4.5+, pysam 0.22+. # Allele-Specific Binding (ASB) **"Identify variants that affect transcription factor or histone modification binding in cis"** -> Compare ChIP-seq read counts at the reference and alternate alleles of heterozygous variants in a single sample. Differential read counts (ALT vs REF at hetSNPs in peaks) reveal allele-specific binding. - CLI (mandatory bias filter): WASP `mapping pipeline` to remove reference-allele mapping bias - CLI (joint association): RASQUAL for cis-QTL + ASB (genotype VCF piped in via tabix) - R (Bayesian beta-binomial): BaalChIP with copy-number-aware overdispersion - CLI (personalized genome): AlleleSeq with phased diploid genome - Statistical test: beta-binomial likelihood ratio or chi-squared on count tables …
Read the whole file at its exact version.
How to install
mdr add fridrichmethod/awesome-skills/bio-chipseq-allele-specific-binding@sha256:b09597e490f250d8The line at the top of this page pins the label git:20260719.44d7640, which is what most people want. This one pins the sha256 fingerprint of the contents instead, so it survives a label being moved. Either way the exact version is written to mdr.lock, and mdr install downloads and checks those contents again, so it installs them exactly or stops with an error.
[](https://markdownregistry.com/a/art_uywg7n4h62lqyyac)
2 badge image fetches in 30 days. What the badge shows.
Versions
The registry has recorded 3 versions of this file, between May 17, 2026 and Jul 19, 2026, about one every 31 days.
| version | committed | commit | size | audit | |
|---|---|---|---|---|---|
| git:20260719.44d7640 latest | 2026-07-19 | 44d7640 | 15,447 B | A | view · diff |
| git:20260528.89ddef6 | 2026-05-28 | 89ddef6 | 14,641 B | A | view · diff |
| git:20260517.81511a7 | 2026-05-17 | 81511a7 | 14,598 B | A | view |
Audit of the latest version
- pass: Frontmatter block present
- pass: Frontmatter declares a name
- pass: Frontmatter declares a description
- pass: Size between 200 bytes and 200 KB (15447 bytes)
- pass: No zero-width or bidi control characters
- pass: No instruction hidden inside an HTML comment
- pass: No link to an exfiltration or paste host
- pass: No credential-shaped string
- pass: No instruction to send local credentials anywhere
- pass: No text hidden with inline styles
- pass: No prompt-injection phrasing
- pass: No curl or wget piped into a shell
- pass: No recursive delete of root, home or parent
- pass: No instruction to read or print local credentials
- pass: No base64 blob over 200 characters
- pass: No link to a raw IP address
- pass: No script tag
Source
fridrichmethod/awesome-skills · 15 stars · license a license file GitHub does not identify · pushed 2026-10-18 · branch main
API
GET https://markdownregistry.com/api/v1/artifacts/art_uywg7n4h62lqyyac GET https://markdownregistry.com/api/v1/resolve?ref=fridrichmethod/awesome-skills/bio-chipseq-allele-specific-binding GET https://markdownregistry.com/api/v1/blob/b09597e490f250d84292c4fd4df6a05a383fa740666b4348cc5839fb78724df4
Your AI assistant does the legwork. You hear about the deals worth your word. Hand yours the standing instructions at modelranch.com and it joins the network that reads files like this one.
Guides: the SKILL.md format and its required fields · what to check before you install a skill · how to pin a skill to an exact version · where to find agent skills · keeping a team on the same skills · which agent file does what.
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