clinvar-database SKILL.md skillA
clinvar-database from marielynneblock/arcanum-artifex is an agent skill: a SKILL.md folder an AI agent loads when a task calls for it.
mdr add marielynneblock/arcanum-artifex/clinvar-database@git:20260710.0115f49Pins git:20260710.0115f49 in mdr.lock. Pin the fingerprint instead.
- Audit grade
- A, 17 of 17 checks passed
- Kind
- SKILL.md skill
- Repository
- marielynneblock/arcanum-artifex
- Path
skills/scientific/clinvar-database/SKILL.md- Versions recorded
- 5
- Latest version
- git:20260710.0115f49, committed Jul 10, 2026
- First version recorded
- Apr 6, 2026
- Size
- 13,283 bytes
- Repository stars
- 4
- License
- none declared
Query NCBI ClinVar for variant clinical significance. Search by gene/position, interpret pathogenicity classifications, access via E-utilities API or FTP, annotate VCFs, for genomic medicine.
Collected from public GitHub. Every version is saved exactly as it was and never changes. Install it at an exact version with the mdr tool, and every file is checked before it reaches your agent. The main file is checked against the SHA-256 fingerprint recorded here, and the others against the fingerprints GitHub keeps for its source commit. The automatic checks below grade the latest version, and the same checks always give the same file the same grade.
What the file says
# ClinVar Database ## Overview ClinVar is NCBI's freely accessible archive of reports on relationships between human genetic variants and phenotypes, with supporting evidence. The database aggregates information about genomic variation and its relationship to human health, providing standardised variant classifications used in clinical genetics and research. ## When to Use This Skill This skill should be used when: - Searching for variants by gene, condition, or clinical significance - Interpreting clinical significance classifications (pathogenic, benign, VUS) - Accessing ClinVar data programmatically via E-utilities API - Downloading and processing bulk data from FTP - Understanding review status and star ratings - Resolving conflicting variant interpretations - Annotating variant call sets with clinical significance ## Core Capabilities ### 1. Search and Query ClinVar #### Web Interface Queries Search ClinVar using the web interface at https://www.ncbi.nlm.nih.gov/clinvar/ **Common search patterns:** - By gene: `BRCA1[gene]` - By clinical significance: `pathogenic[CLNSIG]` - By condition: `breast cancer[disorder]` …
Read the whole file at its exact version.
How to install
mdr add marielynneblock/arcanum-artifex/clinvar-database@sha256:b93fad4c33e89e95The line at the top of this page pins the label git:20260710.0115f49, which is what most people want. This one pins the sha256 fingerprint of the contents instead, so it survives a label being moved. Either way the exact version is written to mdr.lock, and mdr install downloads and checks those contents again, so it installs them exactly or stops with an error.
[](https://markdownregistry.com/a/art_votvbyarbu4buq34)
3 badge image fetches in 30 days. What the badge shows.
Versions
The registry has recorded 5 versions of this file, between Apr 6, 2026 and Jul 10, 2026, about one every 24 days.
| version | committed | commit | size | audit | |
|---|---|---|---|---|---|
| git:20260710.0115f49 latest | 2026-07-10 | 0115f49 | 13,283 B | A | view · diff |
| git:20260710.d1b3aa8 | 2026-07-10 | d1b3aa8 | 13,283 B | A | view · diff |
| git:20260710.ffb3400 | 2026-07-10 | ffb3400 | 13,283 B | A | view · diff |
| git:20260515.b861afb | 2026-05-15 | b861afb | 13,283 B | A | view · diff |
| git:20260406.05dff34 | 2026-04-06 | 05dff34 | 13,284 B | A | view |
Audit of the latest version
- pass: Frontmatter block present
- pass: Frontmatter declares a name
- pass: Frontmatter declares a description
- pass: Size between 200 bytes and 200 KB (13283 bytes)
- pass: No zero-width or bidi control characters
- pass: No instruction hidden inside an HTML comment
- pass: No link to an exfiltration or paste host
- pass: No credential-shaped string
- pass: No instruction to send local credentials anywhere
- pass: No text hidden with inline styles
- pass: No prompt-injection phrasing
- pass: No curl or wget piped into a shell
- pass: No recursive delete of root, home or parent
- pass: No instruction to read or print local credentials
- pass: No base64 blob over 200 characters
- pass: No link to a raw IP address
- pass: No script tag
Source
marielynneblock/arcanum-artifex · 4 stars · license none declared · pushed 2026-09-19 · branch main
API
GET https://markdownregistry.com/api/v1/artifacts/art_votvbyarbu4buq34 GET https://markdownregistry.com/api/v1/resolve?ref=marielynneblock/arcanum-artifex/clinvar-database GET https://markdownregistry.com/api/v1/blob/b93fad4c33e89e95c6ef2df379c4927de1c1bf3889ec4e1b7f6a0bd04de4d77a
Your AI assistant does the legwork. You hear about the deals worth your word. Hand yours the standing instructions at modelranch.com and it joins the network that reads files like this one.
Guides: the SKILL.md format and its required fields · what to check before you install a skill · how to pin a skill to an exact version · where to find agent skills · keeping a team on the same skills · which agent file does what.
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