clinvar-database SKILL.md skillA
clinvar-database from jaechang-hits/sciagent-skills is an agent skill: a SKILL.md folder an AI agent loads when a task calls for it.
mdr add jaechang-hits/sciagent-skills/clinvar-database@git:20260528.3e3f998Pins git:20260528.3e3f998 in mdr.lock. Pin the fingerprint instead.
- Audit grade
- A, 17 of 17 checks passed
- Kind
- SKILL.md skill
- Repository
- jaechang-hits/sciagent-skills
- Path
skills/genomics-bioinformatics/databases/clinvar-database/SKILL.md- Versions recorded
- 1
- Latest version
- git:20260528.3e3f998, committed May 28, 2026
- Size
- 19,710 bytes
- Repository stars
- 381
- License
- a license file GitHub does not identify
Query NCBI ClinVar via E-utilities for variant clinical significance, pathogenicity, disease associations. Search by gene/rsID/condition/review status; returns ClinSig, submitter data, conditions, HGVS. For GWAS use gwas-database; for variant consequence prediction use Ensembl VEP.
Collected from public GitHub. Every version is saved exactly as it was and never changes. Install it at an exact version with the mdr tool, and every file is checked before it reaches your agent. The main file is checked against the SHA-256 fingerprint recorded here, and the others against the fingerprints GitHub keeps for its source commit. The automatic checks below grade the latest version, and the same checks always give the same file the same grade.
What the file says
# ClinVar Clinical Variants Database ## Overview ClinVar is NCBI's public archive of interpretations of variants submitted by clinical laboratories, researchers, and expert panels. It contains 2M+ variants with clinical significance classifications (Pathogenic, Likely Pathogenic, VUS, Likely Benign, Benign) for over 6,000 conditions. Access is free and requires no authentication via NCBI E-utilities. ## When to Use - Checking whether a specific variant (rsID, HGVS, or genomic position) has a clinical significance classification - Retrieving all pathogenic/likely-pathogenic variants in a gene of interest - Identifying conflicting interpretations between submitting laboratories - Pulling condition/phenotype associations for a variant (MIM, MeSH, HPO terms) - Building variant filtering pipelines that prioritize clinically actionable variants - For somatic cancer variants, also check `cosmic-database`; for GWAS associations use `gwas-database` ## Prerequisites - **Python packages**: `requests`, `xml.etree.ElementTree` (stdlib) - **Data requirements**: gene symbols, rsIDs, HGVS strings, or ClinVar Variation IDs …
Read the whole file at its exact version.
How to install
mdr add jaechang-hits/sciagent-skills/clinvar-database@sha256:d7ad592000bd2d13The line at the top of this page pins the label git:20260528.3e3f998, which is what most people want. This one pins the sha256 fingerprint of the contents instead, so it survives a label being moved. Either way the exact version is written to mdr.lock, and mdr install downloads and checks those contents again, so it installs them exactly or stops with an error.
[](https://markdownregistry.com/a/art_kpyxpyyfjvq6ytuj)
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Versions
The registry has recorded 1 version of this file, committed on May 28, 2026.
Audit of the latest version
- pass: Frontmatter block present
- pass: Frontmatter declares a name
- pass: Frontmatter declares a description
- pass: Size between 200 bytes and 200 KB (19710 bytes)
- pass: No zero-width or bidi control characters
- pass: No instruction hidden inside an HTML comment
- pass: No link to an exfiltration or paste host
- pass: No credential-shaped string
- pass: No instruction to send local credentials anywhere
- pass: No text hidden with inline styles
- pass: No prompt-injection phrasing
- pass: No curl or wget piped into a shell
- pass: No recursive delete of root, home or parent
- pass: No instruction to read or print local credentials
- pass: No base64 blob over 200 characters
- pass: No link to a raw IP address
- pass: No script tag
Source
jaechang-hits/sciagent-skills · 381 stars · license a license file GitHub does not identify · pushed 2026-10-16 · branch main
API
GET https://markdownregistry.com/api/v1/artifacts/art_kpyxpyyfjvq6ytuj GET https://markdownregistry.com/api/v1/resolve?ref=jaechang-hits/sciagent-skills/clinvar-database GET https://markdownregistry.com/api/v1/blob/d7ad592000bd2d13059d57879d0a390c06948d916b9e801432db89fdb4f6f058
Your AI assistant does the legwork. You hear about the deals worth your word. Hand yours the standing instructions at modelranch.com and it joins the network that reads files like this one.
Guides: the SKILL.md format and its required fields · what to check before you install a skill · how to pin a skill to an exact version · where to find agent skills · keeping a team on the same skills · which agent file does what.
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