bio-clinical-biostatistics-adaptive-designs SKILL.md skillA
bio-clinical-biostatistics-adaptive-designs from fridrichmethod/awesome-skills is an agent skill: a SKILL.md folder an AI agent loads when a task calls for it.
mdr add fridrichmethod/awesome-skills/bio-clinical-biostatistics-adaptive-designs@git:20260719.44d7640Pins git:20260719.44d7640 in mdr.lock. Pin the fingerprint instead.
- Audit grade
- A, 17 of 17 checks passed
- Kind
- SKILL.md skill
- Repository
- fridrichmethod/awesome-skills
- Path
skills/adaptive-designs/SKILL.md- Versions recorded
- 3
- Latest version
- git:20260719.44d7640, committed Jul 19, 2026
- First version recorded
- May 20, 2026
- Size
- 30,698 bytes
- Repository stars
- 15
- License
- a license file GitHub does not identify
Designs adaptive clinical trials including group-sequential (O'Brien-Fleming, Pocock, Lan-DeMets spending), sample-size re-estimation (blinded Friede-Kieser, unblinded Cui-Hung-Wang, Mehta-Pocock promising zone), seamless Phase 2/3 with treatment-arm selection, population enrichment, and response-adaptive randomisation. Covers FDA 2019 Final Adaptive Designs Guidance, FDA 2022 Master Protocols, and ICH E20 Step 2b/3 draft (June 2025, NOT final). Use when planning interim analyses, sample-size…
Collected from public GitHub. Every version is saved exactly as it was and never changes. Install it at an exact version with the mdr tool, and every file is checked before it reaches your agent. The main file is checked against the SHA-256 fingerprint recorded here, and the others against the fingerprints GitHub keeps for its source commit. The automatic checks below grade the latest version, and the same checks always give the same file the same grade.
What the file says
## Version Compatibility
Reference examples tested with: R `rpact` 4.2+ (Wassmer/Brannath), `gsDesign` 3.6+ and `gsDesign2` 1.1+ (Anderson/Merck), `adaptr`, `simtrial`. Commercial: East/EastHorizon (Cytel), ADDPLAN (ICON), FACTS (Berry Consultants).
Before using code patterns, verify installed versions match. If versions differ:
- R: `packageVersion('<pkg>')` then `?function_name`
- Python adaptive packages are limited; R is the regulatory de facto standard
If code throws an error, introspect the installed package and adapt the example to match the actual API rather than retrying.
# Adaptive Clinical Trial Designs
**"Design an adaptive trial"** -> Pre-specify a design with one or more interim adaptations (early stopping, sample-size re-estimation, treatment selection, population enrichment, randomisation ratio changes) that strongly controls Type-I error at the trial-wide level via combination tests or the Conditional Rejection Probability principle.
## Regulatory Status -- The 2024-2026 Landscape
…Read the whole file at its exact version.
How to install
mdr add fridrichmethod/awesome-skills/bio-clinical-biostatistics-adaptive-designs@sha256:b8424144ac6aa1eaThe line at the top of this page pins the label git:20260719.44d7640, which is what most people want. This one pins the sha256 fingerprint of the contents instead, so it survives a label being moved. Either way the exact version is written to mdr.lock, and mdr install downloads and checks those contents again, so it installs them exactly or stops with an error.
[](https://markdownregistry.com/a/art_wgnoq75dxaocyq2q)
2 badge image fetches in 30 days. What the badge shows.
Versions
The registry has recorded 3 versions of this file, between May 20, 2026 and Jul 19, 2026, about one every 30 days.
| version | committed | commit | size | audit | |
|---|---|---|---|---|---|
| git:20260719.44d7640 latest | 2026-07-19 | 44d7640 | 30,698 B | A | view · diff |
| git:20260531.6e617c4 | 2026-05-31 | 6e617c4 | 30,548 B | A | view · diff |
| git:20260520.e1c72b6 | 2026-05-20 | e1c72b6 | 30,549 B | A | view |
Audit of the latest version
- pass: Frontmatter block present
- pass: Frontmatter declares a name
- pass: Frontmatter declares a description
- pass: Size between 200 bytes and 200 KB (30698 bytes)
- pass: No zero-width or bidi control characters
- pass: No instruction hidden inside an HTML comment
- pass: No link to an exfiltration or paste host
- pass: No credential-shaped string
- pass: No instruction to send local credentials anywhere
- pass: No text hidden with inline styles
- pass: No prompt-injection phrasing
- pass: No curl or wget piped into a shell
- pass: No recursive delete of root, home or parent
- pass: No instruction to read or print local credentials
- pass: No base64 blob over 200 characters
- pass: No link to a raw IP address
- pass: No script tag
Source
fridrichmethod/awesome-skills · 15 stars · license a license file GitHub does not identify · pushed 2026-10-18 · branch main
API
GET https://markdownregistry.com/api/v1/artifacts/art_wgnoq75dxaocyq2q GET https://markdownregistry.com/api/v1/resolve?ref=fridrichmethod/awesome-skills/bio-clinical-biostatistics-adaptive-designs GET https://markdownregistry.com/api/v1/blob/b8424144ac6aa1ea30744ebb3d59f4e5b338a60ffd9ae76ee91a1dfb9f08e07c
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