bindingdb-database SKILL.md skillA
bindingdb-database from fridrichmethod/awesome-skills is an agent skill: a SKILL.md folder an AI agent loads when a task calls for it.
mdr add fridrichmethod/awesome-skills/bindingdb-database@git:20260517.81511a7Pins git:20260517.81511a7 in mdr.lock. Pin the fingerprint instead.
- Audit grade
- A, 17 of 17 checks passed
- Kind
- SKILL.md skill
- Repository
- fridrichmethod/awesome-skills
- Path
skills/bindingdb-database/SKILL.md- Versions recorded
- 1
- Latest version
- git:20260517.81511a7, committed May 17, 2026
- Size
- 12,069 bytes
- Repository stars
- 15
- License
- a license file GitHub does not identify
Query BindingDB for measured drug-target binding affinities (Ki, Kd, IC50, EC50). Search by target (UniProt ID), compound (SMILES/name), or pathogen. Essential for drug discovery, lead optimization, polypharmacology analysis, and structure-activity relationship (SAR) studies.
Collected from public GitHub. Every version is saved exactly as it was and never changes. Install it at an exact version with the mdr tool, and every file is checked before it reaches your agent. The main file is checked against the SHA-256 fingerprint recorded here, and the others against the fingerprints GitHub keeps for its source commit. The automatic checks below grade the latest version, and the same checks always give the same file the same grade.
What the file says
# BindingDB Database ## Overview BindingDB (https://www.bindingdb.org/) is the primary public database of measured drug-protein binding affinities. It contains over 3 million binding data records for ~1.4 million compounds tested against ~9,200 protein targets, curated from scientific literature and patent literature. BindingDB stores quantitative binding measurements (Ki, Kd, IC50, EC50) essential for drug discovery, pharmacology, and computational chemistry research. **Key resources:** - BindingDB website: https://www.bindingdb.org/ - REST API: https://www.bindingdb.org/axis2/services/BDBService - Downloads: https://www.bindingdb.org/bind/chemsearch/marvin/Download.jsp - GitHub: https://github.com/drugilsberg/bindingdb ## When to Use This Skill Use BindingDB when: - **Target-based drug discovery**: What known compounds bind to a target protein? What are their affinities? - **SAR analysis**: How do structural modifications affect binding affinity for a series of analogs? - **Lead compound profiling**: What targets does a compound bind (selectivity/polypharmacology)? - **Benchmark datasets**: Obtain curated protein-ligand affinity data for ML model training …
Read the whole file at its exact version.
How to install
mdr add fridrichmethod/awesome-skills/bindingdb-database@sha256:af78f5c9ce3486faThe line at the top of this page pins the label git:20260517.81511a7, which is what most people want. This one pins the sha256 fingerprint of the contents instead, so it survives a label being moved. Either way the exact version is written to mdr.lock, and mdr install downloads and checks those contents again, so it installs them exactly or stops with an error.
[](https://markdownregistry.com/a/art_5rlb2qhnynfcaooi)
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Versions
The registry has recorded 1 version of this file, committed on May 17, 2026.
Audit of the latest version
- pass: Frontmatter block present
- pass: Frontmatter declares a name
- pass: Frontmatter declares a description
- pass: Size between 200 bytes and 200 KB (12069 bytes)
- pass: No zero-width or bidi control characters
- pass: No instruction hidden inside an HTML comment
- pass: No link to an exfiltration or paste host
- pass: No credential-shaped string
- pass: No instruction to send local credentials anywhere
- pass: No text hidden with inline styles
- pass: No prompt-injection phrasing
- pass: No curl or wget piped into a shell
- pass: No recursive delete of root, home or parent
- pass: No instruction to read or print local credentials
- pass: No base64 blob over 200 characters
- pass: No link to a raw IP address
- pass: No script tag
Source
fridrichmethod/awesome-skills · 15 stars · license a license file GitHub does not identify · pushed 2026-11-02 · branch main
API
GET https://markdownregistry.com/api/v1/artifacts/art_5rlb2qhnynfcaooi GET https://markdownregistry.com/api/v1/resolve?ref=fridrichmethod/awesome-skills/bindingdb-database GET https://markdownregistry.com/api/v1/blob/af78f5c9ce3486faab84be1d0b92f0712efb00e29e56522c34234084417e5098
Your AI assistant does the legwork. You hear about the deals worth your word. Hand yours the standing instructions at modelranch.com and it joins the network that reads files like this one.
Guides: the SKILL.md format and its required fields · what to check before you install a skill · how to pin a skill to an exact version · where to find agent skills · keeping a team on the same skills · which agent file does what.
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