depmap-crispr-essentiality SKILL.md skillA
depmap-crispr-essentiality from jaechang-hits/sciagent-skills is an agent skill: a SKILL.md folder an AI agent loads when a task calls for it.
mdr add jaechang-hits/sciagent-skills/depmap-crispr-essentiality@git:20260528.3e3f998Pins git:20260528.3e3f998 in mdr.lock. Pin the fingerprint instead.
- Audit grade
- A, 17 of 17 checks passed
- Kind
- SKILL.md skill
- Repository
- jaechang-hits/sciagent-skills
- Path
skills/genomics-bioinformatics/databases/depmap-crispr-essentiality/SKILL.md- Versions recorded
- 1
- Latest version
- git:20260528.3e3f998, committed May 28, 2026
- Size
- 14,938 bytes
- Repository stars
- 381
- License
- a license file GitHub does not identify
DepMap CRISPR gene effect (Chronos) analysis: sign convention for essentiality, per-gene NaN-safe Spearman correlation, data loading/alignment. For general NaN-safe correlation see nan-safe-correlation; for quality filtering see degenerate-input-filtering.
Collected from public GitHub. Every version is saved exactly as it was and never changes. Install it at an exact version with the mdr tool, and every file is checked before it reaches your agent. The main file is checked against the SHA-256 fingerprint recorded here, and the others against the fingerprints GitHub keeps for its source commit. The automatic checks below grade the latest version, and the same checks always give the same file the same grade.
What the file says
# DepMap CRISPR Gene Effect Analysis Guide ## Overview This guide covers the correct interpretation and analysis of DepMap CRISPR gene effect (Chronos) data. The most critical and common error in DepMap analyses is failing to negate the CRISPR scores when computing correlations with "essentiality." A secondary but equally damaging mistake is using bulk correlation shortcuts that mishandle per-gene NaN patterns. This guide provides the mandatory sign convention, the correct per-gene NaN-safe Spearman correlation implementation, and data loading/alignment procedures. ## Key Concepts ### DepMap CRISPR Score Convention The CRISPR gene effect score (produced by the Chronos algorithm) quantifies how gene knockout affects cell viability: - **Negative score**: gene knockout reduces cell viability -- the gene is **essential** for that cell line - **Zero score**: no measurable effect on viability - **Positive score**: gene knockout increases viability (rare, may indicate tumor-suppressive behavior) …
Read the whole file at its exact version.
How to install
mdr add jaechang-hits/sciagent-skills/depmap-crispr-essentiality@sha256:338aae9d29133281The line at the top of this page pins the label git:20260528.3e3f998, which is what most people want. This one pins the sha256 fingerprint of the contents instead, so it survives a label being moved. Either way the exact version is written to mdr.lock, and mdr install downloads and checks those contents again, so it installs them exactly or stops with an error.
[](https://markdownregistry.com/a/art_6xsn6srdmyhzzpcn)
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Versions
The registry has recorded 1 version of this file, committed on May 28, 2026.
Audit of the latest version
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Source
jaechang-hits/sciagent-skills · 381 stars · license a license file GitHub does not identify · pushed 2026-10-16 · branch main
API
GET https://markdownregistry.com/api/v1/artifacts/art_6xsn6srdmyhzzpcn GET https://markdownregistry.com/api/v1/resolve?ref=jaechang-hits/sciagent-skills/depmap-crispr-essentiality GET https://markdownregistry.com/api/v1/blob/338aae9d2913328193cd510a03a28f55ba70790334f22359d9244ec0dfce1c79
Your AI assistant does the legwork. You hear about the deals worth your word. Hand yours the standing instructions at modelranch.com and it joins the network that reads files like this one.
Guides: the SKILL.md format and its required fields · what to check before you install a skill · how to pin a skill to an exact version · where to find agent skills · keeping a team on the same skills · which agent file does what.