aipoch/open-science · resources/skills/solublempnn/SKILL.md

solublempnn skillA

Name: solublempnn
Author: aipoch

solublempnn is agent-read markdown (skill) from aipoch/open-science: Inverse-fold a backbone with SolubleMPNN — ProteinMPNN retrained on a soluble-PDB subset (Dauparas et al. 2022) — for sequences biased toward cytosolic expression and reduced aggregation. Reach for this skill when designs from vanilla ProteinMPNN are aggregating or going to inclusion bodies, when redesigning a membrane-adjacent fold for soluble expression, or when an E. coli expression screen is the next step..

Indexed from public GitHub and served as immutable, content-addressed versions. Install it pinned to an exact SHA-256 with the mdr CLI, and every file is verified against the hash recorded here before it reaches your agent. The deterministic audit below grades the latest version, and the same file always earns the same grade.

How to install

Latest version

mdr add aipoch/open-science/solublempnn@git:20260714.a2a3282

Exact content

mdr add aipoch/open-science/solublempnn@sha256:c5c9b5cba2668bfa

Pin to a label to follow the author's releases, or to a sha256 to freeze the exact bytes forever. Either way the resolved hash is written to mdr.lock, and mdr install reproduces it on any machine.

Badge

[![mdr](https://markdownregistry.com/badge/art_cuqf55bkjt7dosqq.svg)](https://markdownregistry.com/a/art_cuqf55bkjt7dosqq)

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Versions

version	committed	commit	size	audit
git:20260714.a2a3282 latest	2026-07-14	a2a3282	4,277 B	A	view

Audit of the latest version

A 17 of 17 checks passed. Deterministic, no model, same answer every run.

pass: Frontmatter block present
pass: Frontmatter declares a name
pass: Frontmatter declares a description
pass: Size between 200 bytes and 200 KB (4277 bytes)
pass: No zero-width or bidi control characters
pass: No instruction hidden inside an HTML comment
pass: No link to an exfiltration or paste host
pass: No credential-shaped string
pass: No instruction to send local credentials anywhere
pass: No text hidden with inline styles
pass: No prompt-injection phrasing
pass: No curl or wget piped into a shell
pass: No recursive delete of root, home or parent
pass: No instruction to read or print local credentials
pass: No base64 blob over 200 characters
pass: No link to a raw IP address
pass: No script tag

Source

GitHub

aipoch/open-science · 3,699 stars · license Apache-2.0 · pushed 2026-09-06 · branch main

API

GET https://markdownregistry.com/api/v1/artifacts/art_cuqf55bkjt7dosqq
GET https://markdownregistry.com/api/v1/resolve?ref=aipoch/open-science/solublempnn
GET https://markdownregistry.com/api/v1/blob/c5c9b5cba2668bfafc54e899e5165a68e07a1425ab25667cab8c86807d3f6e0c