chembl-database-bioactivity SKILL.md skillA
chembl-database-bioactivity from jaechang-hits/sciagent-skills is an agent skill: a SKILL.md folder an AI agent loads when a task calls for it.
mdr add jaechang-hits/sciagent-skills/chembl-database-bioactivity@git:20260522.6a6fd41Pins git:20260522.6a6fd41 in mdr.lock. Pin the fingerprint instead.
- Audit grade
- A, 17 of 17 checks passed
- Kind
- SKILL.md skill
- Repository
- jaechang-hits/sciagent-skills
- Path
skills/structural-biology-drug-discovery/chembl-database-bioactivity/SKILL.md- Versions recorded
- 4
- Latest version
- git:20260522.6a6fd41, committed May 22, 2026
- First version recorded
- Feb 18, 2026
- Size
- 25,803 bytes
- Repository stars
- 381
- License
- a license file GitHub does not identify
Query ChEMBL (2M+ compounds, 19M+ bioactivity measurements, 13K+ targets) via the public REST/JSON API with plain `requests` — no SDK install required. Search compounds, retrieve IC50/Ki/EC50 bioactivities, find target inhibitors, run SAR, access drug mechanism/indication data.
Collected from public GitHub. Every version is saved exactly as it was and never changes. Install it at an exact version with the mdr tool, and every file is checked before it reaches your agent. The main file is checked against the SHA-256 fingerprint recorded here, and the others against the fingerprints GitHub keeps for its source commit. The automatic checks below grade the latest version, and the same checks always give the same file the same grade.
What the file says
# ChEMBL Database — Bioactivity Queries > **Why no SDK?** The `chembl_webresource_client` package is convenient sugar over a public, no-auth REST/JSON API at `https://www.ebi.ac.uk/chembl/api/data/`. When the SDK is unavailable, every operation can be reproduced with plain `requests` and URL parameters. This SKILL.md uses the REST path throughout so the code runs in any environment with `requests` installed. Django-style filter syntax (`field__icontains=…`, `field__lte=…`, `field__range=a,b`) works as URL query parameters. ## Overview ChEMBL is EMBL-EBI's bioactive molecule database: 2M+ compounds, 19M+ bioactivity measurements (IC50, Ki, EC50, Kd, …), 13K+ targets. The REST API at `https://www.ebi.ac.uk/chembl/api/data/` returns JSON (append `.json`) or XML/YAML, requires no authentication, and supports Django-style query filters via URL parameters plus cursor-style pagination via `page_meta.next`. ## When to Use - Finding compounds by name, ChEMBL ID, or physicochemical properties - Querying bioactivity data (IC50, Ki, EC50) for specific targets - Performing similarity or substructure searches using SMILES - Retrieving drug mechanisms of action and clinical indications …
Read the whole file at its exact version.
How to install
mdr add jaechang-hits/sciagent-skills/chembl-database-bioactivity@sha256:beb608cf1936db68The line at the top of this page pins the label git:20260522.6a6fd41, which is what most people want. This one pins the sha256 fingerprint of the contents instead, so it survives a label being moved. Either way the exact version is written to mdr.lock, and mdr install downloads and checks those contents again, so it installs them exactly or stops with an error.
[](https://markdownregistry.com/a/art_dxonc4hdb6quggzq)
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Versions
The registry has recorded 4 versions of this file, between Feb 18, 2026 and May 22, 2026, about one every 31 days.
| version | committed | commit | size | audit | |
|---|---|---|---|---|---|
| git:20260522.6a6fd41 latest | 2026-05-22 | 6a6fd41 | 25,803 B | A | view · diff |
| git:20260428.81ea2d2 | 2026-04-28 | 81ea2d2 | 18,180 B | A | view · diff |
| git:20260409.a3b01d0 | 2026-04-09 | a3b01d0 | 18,289 B | A | view · diff |
| git:20260218.8df1694 | 2026-02-18 | 8df1694 | 18,328 B | A | view |
Audit of the latest version
- pass: Frontmatter block present
- pass: Frontmatter declares a name
- pass: Frontmatter declares a description
- pass: Size between 200 bytes and 200 KB (25803 bytes)
- pass: No zero-width or bidi control characters
- pass: No instruction hidden inside an HTML comment
- pass: No link to an exfiltration or paste host
- pass: No credential-shaped string
- pass: No instruction to send local credentials anywhere
- pass: No text hidden with inline styles
- pass: No prompt-injection phrasing
- pass: No curl or wget piped into a shell
- pass: No recursive delete of root, home or parent
- pass: No instruction to read or print local credentials
- pass: No base64 blob over 200 characters
- pass: No link to a raw IP address
- pass: No script tag
Source
jaechang-hits/sciagent-skills · 381 stars · license a license file GitHub does not identify · pushed 2026-10-16 · branch main
API
GET https://markdownregistry.com/api/v1/artifacts/art_dxonc4hdb6quggzq GET https://markdownregistry.com/api/v1/resolve?ref=jaechang-hits/sciagent-skills/chembl-database-bioactivity GET https://markdownregistry.com/api/v1/blob/beb608cf1936db68572968817823ad1fcae5294f3c6d3f37196a213a2bd64c77
Your AI assistant does the legwork. You hear about the deals worth your word. Hand yours the standing instructions at modelranch.com and it joins the network that reads files like this one.
Guides: the SKILL.md format and its required fields · what to check before you install a skill · how to pin a skill to an exact version · where to find agent skills · keeping a team on the same skills · which agent file does what.