gtopdb-database SKILL.md skillA
gtopdb-database from jaechang-hits/sciagent-skills is an agent skill: a SKILL.md folder an AI agent loads when a task calls for it.
mdr add jaechang-hits/sciagent-skills/gtopdb-database@git:20260522.6a6fd41Pins git:20260522.6a6fd41 in mdr.lock. Pin the fingerprint instead.
- Audit grade
- A, 17 of 17 checks passed
- Kind
- SKILL.md skill
- Repository
- jaechang-hits/sciagent-skills
- Path
skills/structural-biology-drug-discovery/gtopdb-database/SKILL.md- Versions recorded
- 3
- Latest version
- git:20260522.6a6fd41, committed May 22, 2026
- First version recorded
- Feb 18, 2026
- Size
- 19,496 bytes
- Repository stars
- 381
- License
- a license file GitHub does not identify
Query IUPHAR/BPS Guide to Pharmacology (GtoPdb) for receptor-ligand interactions, target/ligand metadata, families, and approved drugs. Affinities (pKi/pIC50/pKd), action (Agonist/Antagonist/etc.), species, structures (SMILES/InChI). No auth. Always resolve targets via geneSymbol/accession; most metadata lives in sub-resources (/databaseLinks, /structure, /synonyms).
Collected from public GitHub. Every version is saved exactly as it was and never changes. Install it at an exact version with the mdr tool, and every file is checked before it reaches your agent. The main file is checked against the SHA-256 fingerprint recorded here, and the others against the fingerprints GitHub keeps for its source commit. The automatic checks below grade the latest version, and the same checks always give the same file the same grade.
What the file says
# Guide to Pharmacology (GtoPdb) Database
## Overview
The IUPHAR/BPS Guide to Pharmacology (GtoPdb) catalogues drug targets, ligands, and quantitative interactions across receptor pharmacology. The web services REST API at `https://www.guidetopharmacology.org/services/` returns JSON for targets, ligands, interactions, and family hierarchies. Base records are intentionally lean — gene symbols, UniProt accessions, ChEMBL IDs, SMILES/InChI all live in sub-resources (`/targets/{id}/databaseLinks`, `/targets/{id}/synonyms`, `/ligands/{id}/structure`, `/ligands/{id}/databaseLinks`). No authentication required.
## When to Use
- Looking up the affinity (pKi/pIC50/pKd) of a ligand at a specific target
- Listing all annotated ligands for a receptor (e.g., μ-opioid receptor / OPRM1)
- Finding the approval status of a ligand (`approved=true`) and its cross-references (PubChem CID, ChEMBL ID, DrugBank ID)
- Retrieving the IUPHAR family hierarchy (867 families) for receptor classification
- Pulling structure descriptors (SMILES, InChI, InChIKey) for chemoinformatics
- Mapping HGNC symbol → UniProt → GtoPdb target ID for cross-database integration
…Read the whole file at its exact version.
How to install
mdr add jaechang-hits/sciagent-skills/gtopdb-database@sha256:f3e488e275bbbcd4The line at the top of this page pins the label git:20260522.6a6fd41, which is what most people want. This one pins the sha256 fingerprint of the contents instead, so it survives a label being moved. Either way the exact version is written to mdr.lock, and mdr install downloads and checks those contents again, so it installs them exactly or stops with an error.
[](https://markdownregistry.com/a/art_moxupy33kysc3tes)
1 badge image fetches in 30 days. What the badge shows.
Versions
The registry has recorded 3 versions of this file, between Feb 18, 2026 and May 22, 2026, about one every 46 days.
| version | committed | commit | size | audit | |
|---|---|---|---|---|---|
| git:20260522.6a6fd41 latest | 2026-05-22 | 6a6fd41 | 19,496 B | A | view · diff |
| git:20260428.81ea2d2 | 2026-04-28 | 81ea2d2 | 35,196 B | A | view · diff |
| git:20260218.8df1694 | 2026-02-18 | 8df1694 | 35,319 B | A | view |
Audit of the latest version
- pass: Frontmatter block present
- pass: Frontmatter declares a name
- pass: Frontmatter declares a description
- pass: Size between 200 bytes and 200 KB (19496 bytes)
- pass: No zero-width or bidi control characters
- pass: No instruction hidden inside an HTML comment
- pass: No link to an exfiltration or paste host
- pass: No credential-shaped string
- pass: No instruction to send local credentials anywhere
- pass: No text hidden with inline styles
- pass: No prompt-injection phrasing
- pass: No curl or wget piped into a shell
- pass: No recursive delete of root, home or parent
- pass: No instruction to read or print local credentials
- pass: No base64 blob over 200 characters
- pass: No link to a raw IP address
- pass: No script tag
Source
jaechang-hits/sciagent-skills · 381 stars · license a license file GitHub does not identify · pushed 2026-10-16 · branch main
API
GET https://markdownregistry.com/api/v1/artifacts/art_moxupy33kysc3tes GET https://markdownregistry.com/api/v1/resolve?ref=jaechang-hits/sciagent-skills/gtopdb-database GET https://markdownregistry.com/api/v1/blob/f3e488e275bbbcd4c2145b819217e95e8363f2abf6d65224332b09a8aaf40ae3
Your AI assistant does the legwork. You hear about the deals worth your word. Hand yours the standing instructions at modelranch.com and it joins the network that reads files like this one.
Guides: the SKILL.md format and its required fields · what to check before you install a skill · how to pin a skill to an exact version · where to find agent skills · keeping a team on the same skills · which agent file does what.