regulomedb-database SKILL.md skillA
regulomedb-database from jaechang-hits/sciagent-skills is an agent skill: a SKILL.md folder an AI agent loads when a task calls for it.
mdr add jaechang-hits/sciagent-skills/regulomedb-database@git:20260528.3e3f998Pins git:20260528.3e3f998 in mdr.lock. Pin the fingerprint instead.
- Audit grade
- A, 17 of 17 checks passed
- Kind
- SKILL.md skill
- Repository
- jaechang-hits/sciagent-skills
- Path
skills/genomics-bioinformatics/databases/regulomedb-database/SKILL.md- Versions recorded
- 1
- Latest version
- git:20260528.3e3f998, committed May 28, 2026
- Size
- 21,261 bytes
- Repository stars
- 381
- License
- a license file GitHub does not identify
Query RegulomeDB v2 GET REST API to score variants for regulatory function and retrieve overlapping evidence (TF binding, histone marks, DNase peaks, footprints, motifs, eQTLs, chromatin state). Scores range 1a (strongest) to 7 (none). Use for GWAS hit prioritization, regulatory variant annotation, cis-regulatory discovery. Use clinvar-database for pathogenicity; gwas-database for trait associations.
Collected from public GitHub. Every version is saved exactly as it was and never changes. Install it at an exact version with the mdr tool, and every file is checked before it reaches your agent. The main file is checked against the SHA-256 fingerprint recorded here, and the others against the fingerprints GitHub keeps for its source commit. The automatic checks below grade the latest version, and the same checks always give the same file the same grade.
What the file says
# RegulomeDB Database ## Overview RegulomeDB integrates large-scale functional genomics data (ENCODE, Roadmap Epigenomics) to score genetic variants for regulatory potential. Each variant receives a ranking from 1a (highest regulatory confidence: eQTL + TF + DNase + motif + chromatin) to 7 (no known regulatory function). The v2 API is exposed as **GET** `https://regulomedb.org/regulome-search/`; the legacy POST `/regulome-search/`, POST `/regulome-summary/`, and GET `/regulome-datasets/` JSON endpoints are no longer functional (return `regulome-notfound` stubs or 500). Access is free and requires no authentication. ## When to Use - Prioritizing GWAS hits for regulatory follow-up — identify which SNPs land in active regulatory elements - Annotating a VCF or variant list with regulatory scores to filter to functionally relevant variants - Identifying which transcription factors bind near a variant of interest (via the `@graph` evidence rows) - Checking whether a non-coding variant overlaps a QTL and active chromatin simultaneously (`features.QTL`) - Retrieving all annotated rsIDs in a genomic region for cis-regulatory analysis (region query with `nearby_snps`) …
Read the whole file at its exact version.
How to install
mdr add jaechang-hits/sciagent-skills/regulomedb-database@sha256:c2507a35bed414f2The line at the top of this page pins the label git:20260528.3e3f998, which is what most people want. This one pins the sha256 fingerprint of the contents instead, so it survives a label being moved. Either way the exact version is written to mdr.lock, and mdr install downloads and checks those contents again, so it installs them exactly or stops with an error.
[](https://markdownregistry.com/a/art_oha2pka4nntrmpzn)
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Versions
The registry has recorded 1 version of this file, committed on May 28, 2026.
Audit of the latest version
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- pass: No zero-width or bidi control characters
- pass: No instruction hidden inside an HTML comment
- pass: No link to an exfiltration or paste host
- pass: No credential-shaped string
- pass: No instruction to send local credentials anywhere
- pass: No text hidden with inline styles
- pass: No prompt-injection phrasing
- pass: No curl or wget piped into a shell
- pass: No recursive delete of root, home or parent
- pass: No instruction to read or print local credentials
- pass: No base64 blob over 200 characters
- pass: No link to a raw IP address
- pass: No script tag
Source
jaechang-hits/sciagent-skills · 381 stars · license a license file GitHub does not identify · pushed 2026-10-16 · branch main
API
GET https://markdownregistry.com/api/v1/artifacts/art_oha2pka4nntrmpzn GET https://markdownregistry.com/api/v1/resolve?ref=jaechang-hits/sciagent-skills/regulomedb-database GET https://markdownregistry.com/api/v1/blob/c2507a35bed414f25cc62faa3eaf80cc2c6e33bf34cecc36542c9a5e9fe052d8
Your AI assistant does the legwork. You hear about the deals worth your word. Hand yours the standing instructions at modelranch.com and it joins the network that reads files like this one.
Guides: the SKILL.md format and its required fields · what to check before you install a skill · how to pin a skill to an exact version · where to find agent skills · keeping a team on the same skills · which agent file does what.