bio-clinical-biostatistics-bayesian-trials SKILL.md skillA
bio-clinical-biostatistics-bayesian-trials from fridrichmethod/awesome-skills is an agent skill: a SKILL.md folder an AI agent loads when a task calls for it.
mdr add fridrichmethod/awesome-skills/bio-clinical-biostatistics-bayesian-trials@git:20260719.44d7640Pins git:20260719.44d7640 in mdr.lock. Pin the fingerprint instead.
- Audit grade
- A, 17 of 17 checks passed
- Kind
- SKILL.md skill
- Repository
- fridrichmethod/awesome-skills
- Path
skills/bayesian-trials/SKILL.md- Versions recorded
- 4
- Latest version
- git:20260719.44d7640, committed Jul 19, 2026
- First version recorded
- May 20, 2026
- Size
- 31,592 bytes
- Repository stars
- 15
- License
- a license file GitHub does not identify
Designs Bayesian clinical trials including Phase I dose-finding (BOIN, CRM, EWOC, mTPI-2), meta-analytic-predictive (MAP) priors with robust mixtures for external data borrowing, EXNEX for basket trials, hierarchical models for safety AE (Berry-Berry), Bayesian platform trials (I-SPY 2, GBM AGILE, REMAP-CAP), and posterior probability stopping rules. Covers FDA Bayesian Devices Guidance (2010), FDA Bayesian Methodology in Drugs Draft (January 2026), BOIN Fit-for-Purpose qualification…
Collected from public GitHub. Every version is saved exactly as it was and never changes. Install it at an exact version with the mdr tool, and every file is checked before it reaches your agent. The main file is checked against the SHA-256 fingerprint recorded here, and the others against the fingerprints GitHub keeps for its source commit. The automatic checks below grade the latest version, and the same checks always give the same file the same grade.
What the file says
## Version Compatibility
Reference examples tested with: R `RBesT` 1.7+ (Roche), `OncoBayes2` 0.8+ (Novartis), `BOIN` 2.7+, `dfcrm` 0.2-2+, `escalation` 0.1+, `trialr` 0.1.6+, `bayesDP`, `psborrow2` (FDA-supported), `rstan` / `cmdstanr`, `brms`. Legacy: `JAGS`, `WinBUGS`.
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# Bayesian Clinical Trials
**"Design a Bayesian clinical trial"** -> Specify a prior, likelihood, and decision rule with frequentist operating characteristics demonstrated via simulation; for dose-finding use FDA-endorsed BOIN; for borrowing use robust MAP priors; for adaptive platforms use posterior probability of efficacy stopping with simulation-calibrated thresholds.
## Regulatory Status -- The 2024-2026 Bayesian Pivot
…Read the whole file at its exact version.
How to install
mdr add fridrichmethod/awesome-skills/bio-clinical-biostatistics-bayesian-trials@sha256:439379d8971621fcThe line at the top of this page pins the label git:20260719.44d7640, which is what most people want. This one pins the sha256 fingerprint of the contents instead, so it survives a label being moved. Either way the exact version is written to mdr.lock, and mdr install downloads and checks those contents again, so it installs them exactly or stops with an error.
[](https://markdownregistry.com/a/art_uhc3uz2yprcwdl7e)
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Versions
The registry has recorded 4 versions of this file, between May 20, 2026 and Jul 19, 2026, about one every 20 days.
| version | committed | commit | size | audit | |
|---|---|---|---|---|---|
| git:20260719.44d7640 latest | 2026-07-19 | 44d7640 | 31,592 B | A | view · diff |
| git:20260531.6e617c4 | 2026-05-31 | 6e617c4 | 31,295 B | A | view · diff |
| git:20260528.89ddef6 | 2026-05-28 | 89ddef6 | 31,296 B | A | view · diff |
| git:20260520.e1c72b6 | 2026-05-20 | e1c72b6 | 30,945 B | A | view |
Audit of the latest version
- pass: Frontmatter block present
- pass: Frontmatter declares a name
- pass: Frontmatter declares a description
- pass: Size between 200 bytes and 200 KB (31592 bytes)
- pass: No zero-width or bidi control characters
- pass: No instruction hidden inside an HTML comment
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- pass: No curl or wget piped into a shell
- pass: No recursive delete of root, home or parent
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Source
fridrichmethod/awesome-skills · 15 stars · license a license file GitHub does not identify · pushed 2026-11-02 · branch main
API
GET https://markdownregistry.com/api/v1/artifacts/art_uhc3uz2yprcwdl7e GET https://markdownregistry.com/api/v1/resolve?ref=fridrichmethod/awesome-skills/bio-clinical-biostatistics-bayesian-trials GET https://markdownregistry.com/api/v1/blob/439379d8971621fc180091ca1b18b51f628efb8a75e3279d0be658dba47c2af4
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