bio-clinical-biostatistics-bayesian-trials SKILL.md skillA
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mdr add pku-yuangroup/openai4s/bio-clinical-biostatistics-bayesian-trials@git:20260821.2d1b678Pins git:20260821.2d1b678 in mdr.lock. Pin the fingerprint instead.
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- MIT
Designs Bayesian clinical trials including Phase I dose-finding (BOIN, CRM, EWOC, mTPI-2), meta-analytic-predictive (MAP) priors with robust mixtures for external data borrowing, EXNEX for basket trials, hierarchical models for safety AE (Berry-Berry), Bayesian platform trials (I-SPY 2, GBM AGILE, REMAP-CAP), and posterior probability stopping rules. Covers FDA Bayesian Devices Guidance (2010), FDA Bayesian Methodology in Drugs Draft (January 2026), BOIN Fit-for-Purpose qualification…
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What the file says
## Version Compatibility
Reference examples tested with: R `RBesT` 1.7+ (Roche), `OncoBayes2` 0.8+ (Novartis), `BOIN` 2.7+, `dfcrm` 0.2-2+, `escalation` 0.1+, `trialr` 0.1.6+, `bayesDP`, `psborrow2` (FDA-supported), `rstan` / `cmdstanr`, `brms`. Legacy: `JAGS`, `WinBUGS`.
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# Bayesian Clinical Trials
**"Design a Bayesian clinical trial"** -> Specify a prior, likelihood, and decision rule with frequentist operating characteristics demonstrated via simulation; for dose-finding use FDA-endorsed BOIN; for borrowing use robust MAP priors; for adaptive platforms use posterior probability of efficacy stopping with simulation-calibrated thresholds.
## Regulatory Status -- The 2024-2026 Bayesian Pivot
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How to install
mdr add pku-yuangroup/openai4s/bio-clinical-biostatistics-bayesian-trials@sha256:500ed67a0ad00282The line at the top of this page pins the label git:20260821.2d1b678, which is what most people want. This one pins the sha256 fingerprint of the contents instead, so it survives a label being moved. Either way the exact version is written to mdr.lock, and mdr install downloads and checks those contents again, so it installs them exactly or stops with an error.
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The registry has recorded 1 version of this file, committed on Aug 21, 2026.
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Source
pku-yuangroup/openai4s · 662 stars · license MIT · pushed 2026-11-03 · branch main
API
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