bio-causal-genomics-pleiotropy-detection SKILL.md skillA
bio-causal-genomics-pleiotropy-detection from fridrichmethod/awesome-skills is an agent skill: a SKILL.md folder an AI agent loads when a task calls for it.
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Detect and correct for horizontal pleiotropy in Mendelian randomization analyses using MR-PRESSO for outlier removal, MR-Egger regression for directional pleiotropy, and Steiger filtering for variant directionality. Use when validating MR results, detecting pleiotropic instruments, or running sensitivity analyses for causal inference.
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What the file says
## Version Compatibility
Reference examples tested with: MR-PRESSO 1.0+, TwoSampleMR 0.5+
Before using code patterns, verify installed versions match. If versions differ:
- R: `packageVersion("<pkg>")` then `?function_name` to verify parameters
If code throws ImportError, AttributeError, or TypeError, introspect the installed
package and adapt the example to match the actual API rather than retrying.
# Pleiotropy Detection
**"Check my MR results for pleiotropic bias"** → Detect and correct for horizontal pleiotropy using outlier removal (MR-PRESSO), directional pleiotropy testing (MR-Egger intercept), and variant directionality filtering (Steiger) to validate causal inference results.
- R: `MRPRESSO::mr_presso()` for global and distortion tests
- R: `TwoSampleMR::mr_egger_regression()` for Egger intercept test
## Overview
Horizontal pleiotropy violates the exclusion restriction assumption of MR: instruments
affect the outcome through pathways other than the exposure. Detecting and correcting
for pleiotropy is essential for valid causal inference.
Types of pleiotropy:
- **Vertical** (mediated): Instrument -> exposure -> outcome (valid, not a problem)
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How to install
mdr add fridrichmethod/awesome-skills/bio-causal-genomics-pleiotropy-detection@sha256:2052d13858af64daThe line at the top of this page pins the label git:20260517.81511a7, which is what most people want. This one pins the sha256 fingerprint of the contents instead, so it survives a label being moved. Either way the exact version is written to mdr.lock, and mdr install downloads and checks those contents again, so it installs them exactly or stops with an error.
[](https://markdownregistry.com/a/art_v36ibxls7pz5vkdz)
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The registry has recorded 1 version of this file, committed on May 17, 2026.
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Source
fridrichmethod/awesome-skills · 15 stars · license a license file GitHub does not identify · pushed 2026-11-02 · branch main
API
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