bio-causal-genomics-pleiotropy-detection SKILL.md skillA
bio-causal-genomics-pleiotropy-detection from pku-yuangroup/openai4s is an agent skill: a SKILL.md folder an AI agent loads when a task calls for it.
mdr add pku-yuangroup/openai4s/bio-causal-genomics-pleiotropy-detection@git:20260821.2d1b678Pins git:20260821.2d1b678 in mdr.lock. Pin the fingerprint instead.
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- pku-yuangroup/openai4s
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skills/bioskills/bio-causal-genomics-pleiotropy-detection/SKILL.md- Versions recorded
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- git:20260821.2d1b678, committed Aug 21, 2026
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- MIT
Detect and adjust for horizontal pleiotropy in two-sample Mendelian randomization by distinguishing uncorrelated (UHP) from correlated (CHP) pleiotropy and choosing among Egger, MR-PRESSO, MR-RAPS, CAUSE, LHC-MR, LCV, MR-Clust, MR-Mix, and contamination-mixture methods. Use when validating an MR causal claim, running the STROBE-MR sensitivity battery, suspecting a shared heritable confounder, working under weak-instrument or polygenic-exposure regimes, or reconciling discordant estimates…
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What the file says
## Version Compatibility
Reference examples tested with: TwoSampleMR 0.5.11+, MendelianRandomization 0.9.0+, MR-PRESSO 1.0+, CAUSE 1.2.0+, MR-Clust 0.1.0+, MRMix 0.1+, mr.raps 0.4.1+ (GitHub), LHC-MR 0.0.0.9000+ (GitHub), LCV (script-based, no version tag), simex 1.8+.
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# Pleiotropy Detection in Mendelian Randomization
**"Validate my MR result against pleiotropic bias"** -> Decompose violations of the exclusion-restriction assumption into uncorrelated horizontal pleiotropy (UHP, addressable by Egger / median / mode / MR-PRESSO) and correlated horizontal pleiotropy (CHP, addressable only by CAUSE / LHC-MR / LCV), then run a method battery whose assumptions span both regimes.
- R: `TwoSampleMR::mr()` (IVW + Egger + median + mode), `mr_pleiotropy_test()`, `mr_heterogeneity()`, `mr_leaveoneout()`, `directionality_test()`
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How to install
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The registry has recorded 1 version of this file, committed on Aug 21, 2026.
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Source
pku-yuangroup/openai4s · 662 stars · license MIT · pushed 2026-11-03 · branch main
API
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