disease-research skillA
disease-research is agent-read markdown (skill) from ammawla/encode-toolkit: Use ENCODE functional genomics data for disease mechanism research. Use when the user wants to connect GWAS variants to regulatory elements, annotate disease-associated loci with functional data, identify therapeutic targets from epigenomic data, build disease regulatory models, cross-reference with clinical trials and drug databases, or conduct any disease-focused, pathology-driven, or clinical variant interpretation workflow. Covers the full pipeline from disease-tissue mapping through GWAS va.
Indexed from public GitHub and served as immutable, content-addressed versions. Install it pinned to an exact SHA-256 with the mdr CLI, and every file is verified against the hash recorded here before it reaches your agent. The deterministic audit below grades the latest version, and the same file always earns the same grade.
What the file says
# Disease Research with ENCODE Functional Genomics ## When to Use - User wants to connect GWAS variants to ENCODE regulatory elements for disease mechanism research - User asks about "disease", "pathology", "therapeutic targets", "GWAS interpretation", or "clinical variants" - User needs to annotate disease-associated loci with functional genomics data from ENCODE - User wants to identify drug targets from epigenomic evidence using Open Targets integration - Example queries: "find enhancers disrupted by diabetes GWAS hits", "identify drug targets from ChIP-seq data", "connect my disease variants to regulatory elements" Leverage ENCODE's 926,535 cCREs and multi-layer functional data to understand disease mechanisms, interpret disease-associated variants, identify therapeutic targets, and connect genomic findings to clinical applications. ## Scientific Rationale **The question**: "How can ENCODE functional genomics help me understand a disease's molecular mechanisms and identify actionable targets?" …
Read the whole file at its exact version.
How to install
mdr add ammawla/encode-toolkit/disease-research@git:20260921.4ba10c6mdr add ammawla/encode-toolkit/disease-research@sha256:44237c33b54fb447Pin to a label to follow the author's releases, or to a sha256 to freeze the exact bytes forever. Either way the resolved hash is written to mdr.lock, and mdr install reproduces it on any machine.
[](https://markdownregistry.com/a/art_yc6vyqwtbock2tle)
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Versions
| version | committed | commit | size | audit | |
|---|---|---|---|---|---|
| git:20260921.4ba10c6 latest | 2026-09-21 | 4ba10c6 | 24,679 B | A | view · diff |
| git:20260920.6050003 | 2026-09-20 | 6050003 | 24,667 B | A | view · diff |
| git:20260920.992a807 | 2026-09-20 | 992a807 | 24,182 B | A | view · diff |
| git:20260321.d9029d0 | 2026-03-21 | d9029d0 | 24,236 B | A | view · diff |
| git:20260308.ca46af5 | 2026-03-08 | ca46af5 | 24,230 B | A | view |
Audit of the latest version
- pass: Frontmatter block present
- pass: Frontmatter declares a name
- pass: Frontmatter declares a description
- pass: Size between 200 bytes and 200 KB (24679 bytes)
- pass: No zero-width or bidi control characters
- pass: No instruction hidden inside an HTML comment
- pass: No link to an exfiltration or paste host
- pass: No credential-shaped string
- pass: No instruction to send local credentials anywhere
- pass: No text hidden with inline styles
- pass: No prompt-injection phrasing
- pass: No curl or wget piped into a shell
- pass: No recursive delete of root, home or parent
- pass: No instruction to read or print local credentials
- pass: No base64 blob over 200 characters
- pass: No link to a raw IP address
- pass: No script tag
Source
ammawla/encode-toolkit · 20 stars · license AGPL-3.0 · pushed 2026-09-21 · branch main
API
GET https://markdownregistry.com/api/v1/artifacts/art_yc6vyqwtbock2tle GET https://markdownregistry.com/api/v1/resolve?ref=ammawla/encode-toolkit/disease-research GET https://markdownregistry.com/api/v1/blob/44237c33b54fb44796b0bcc2150a82a812ff040964c7011c3fcec3b5df888cd8
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