bio-causal-genomics-mendelian-randomization SKILL.md skillA
bio-causal-genomics-mendelian-randomization from fridrichmethod/awesome-skills is an agent skill: a SKILL.md folder an AI agent loads when a task calls for it.
mdr add fridrichmethod/awesome-skills/bio-causal-genomics-mendelian-randomization@git:20260517.81511a7Pins git:20260517.81511a7 in mdr.lock. Pin the fingerprint instead.
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- git:20260517.81511a7, committed May 17, 2026
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Estimate causal effects between exposures and outcomes using genetic variants as instrumental variables with TwoSampleMR. Implements IVW, MR-Egger, weighted median, and MR-PRESSO methods for robust causal inference from GWAS summary statistics. Use when testing whether an exposure causally affects an outcome using genetic instruments.
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What the file says
## Version Compatibility
Reference examples tested with: TwoSampleMR 0.5+, MendelianRandomization 0.9+
Before using code patterns, verify installed versions match. If versions differ:
- R: `packageVersion("<pkg>")` then `?function_name` to verify parameters
If code throws ImportError, AttributeError, or TypeError, introspect the installed
package and adapt the example to match the actual API rather than retrying.
# Mendelian Randomization
**"Test whether my exposure causally affects this outcome using GWAS data"** → Use genetic variants as instrumental variables to estimate causal effects from GWAS summary statistics, applying IVW, MR-Egger, and weighted median methods for robust inference.
- R: `TwoSampleMR::mr()` for multi-method causal estimation
- R: `MendelianRandomization::mr_ivw()` for individual methods
## Core Concepts
Mendelian randomization (MR) uses genetic variants as instrumental variables (IVs) to estimate
causal effects of exposures on outcomes. Valid instruments must satisfy three assumptions:
1. **Relevance** - The variant is associated with the exposure (F-statistic > 10)
2. **Independence** - The variant is not associated with confounders
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How to install
mdr add fridrichmethod/awesome-skills/bio-causal-genomics-mendelian-randomization@sha256:4252e2bd81fb8267The line at the top of this page pins the label git:20260517.81511a7, which is what most people want. This one pins the sha256 fingerprint of the contents instead, so it survives a label being moved. Either way the exact version is written to mdr.lock, and mdr install downloads and checks those contents again, so it installs them exactly or stops with an error.
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The registry has recorded 1 version of this file, committed on May 17, 2026.
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Source
fridrichmethod/awesome-skills · 15 stars · license a license file GitHub does not identify · pushed 2026-11-02 · branch main
API
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