bio-causal-genomics-mendelian-randomization SKILL.md skillA
bio-causal-genomics-mendelian-randomization from pku-yuangroup/openai4s is an agent skill: a SKILL.md folder an AI agent loads when a task calls for it.
mdr add pku-yuangroup/openai4s/bio-causal-genomics-mendelian-randomization@git:20260821.2d1b678Pins git:20260821.2d1b678 in mdr.lock. Pin the fingerprint instead.
- Audit grade
- A, 17 of 17 checks passed
- Kind
- SKILL.md skill
- Repository
- pku-yuangroup/openai4s
- Path
skills/bioskills/bio-causal-genomics-mendelian-randomization/SKILL.md- Versions recorded
- 1
- Latest version
- git:20260821.2d1b678, committed Aug 21, 2026
- Size
- 34,947 bytes
- Repository stars
- 662
- License
- MIT
Estimate causal effects of an exposure on an outcome from GWAS summary statistics using genetic instruments. Implements IVW (fixed/random), MR-Egger, weighted median/mode, MR-RAPS, CAUSE, GSMR-HEIDI, MR-PRESSO, MVMR, MR-Clust, LCV, and LHC-MR via TwoSampleMR, MendelianRandomization, MR-PRESSO, cause, and lhcMR. Use when testing causal direction between traits, evaluating drug-target effects via cis-pQTL/cis-eQTL, performing multivariable mediation MR, distinguishing causation from correlated…
Collected from public GitHub. Every version is saved exactly as it was and never changes. Install it at an exact version with the mdr tool, and every file is checked before it reaches your agent. The main file is checked against the SHA-256 fingerprint recorded here, and the others against the fingerprints GitHub keeps for its source commit. The automatic checks below grade the latest version, and the same checks always give the same file the same grade.
What the file says
## Version Compatibility
Reference examples tested with: TwoSampleMR 0.6.0+, MendelianRandomization 0.10+, MR-PRESSO 1.0+, cause 1.2+, MVMR 0.4+, ieugwasr 1.0+, MRlap 0.0.3.2+, coloc 5.2+, mrclust 0.1+, lhcMR 0.0.1+, R 4.4+. Both TwoSampleMR 0.6.0 and ieugwasr 1.0 are the JWT-transition versions; older versions still expect deprecated OAuth.
Before using code patterns, verify installed versions match. If versions differ:
- R: `packageVersion('<pkg>')` then `?function_name` to verify parameters
- CLI (plink, GCTA-GSMR): `<tool> --version` then `<tool> --help`
If code throws an error referencing a function that has moved (e.g. `ieugwasr::ld_clump` vs `TwoSampleMR::clump_data`) or an OAuth token failure, introspect the installed API and adapt the example rather than retrying.
# Mendelian Randomization
…Read the whole file at its exact version.
How to install
mdr add pku-yuangroup/openai4s/bio-causal-genomics-mendelian-randomization@sha256:4e771465992d1d21The line at the top of this page pins the label git:20260821.2d1b678, which is what most people want. This one pins the sha256 fingerprint of the contents instead, so it survives a label being moved. Either way the exact version is written to mdr.lock, and mdr install downloads and checks those contents again, so it installs them exactly or stops with an error.
[](https://markdownregistry.com/a/art_ksfpskdriyjwafoj)
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Versions
The registry has recorded 1 version of this file, committed on Aug 21, 2026.
Audit of the latest version
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Source
pku-yuangroup/openai4s · 662 stars · license MIT · pushed 2026-11-03 · branch main
API
GET https://markdownregistry.com/api/v1/artifacts/art_ksfpskdriyjwafoj GET https://markdownregistry.com/api/v1/resolve?ref=pku-yuangroup/openai4s/bio-causal-genomics-mendelian-randomization GET https://markdownregistry.com/api/v1/blob/4e771465992d1d21fb4afeed6963daa6b3f65c81c3a7aea182d49fa57279af1a
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