opentargets-database SKILL.md skillA
opentargets-database from jaechang-hits/sciagent-skills is an agent skill: a SKILL.md folder an AI agent loads when a task calls for it.
mdr add jaechang-hits/sciagent-skills/opentargets-database@git:20260522.d4a4f76Pins git:20260522.d4a4f76 in mdr.lock. Pin the fingerprint instead.
- Audit grade
- A, 17 of 17 checks passed
- Kind
- SKILL.md skill
- Repository
- jaechang-hits/sciagent-skills
- Path
skills/structural-biology-drug-discovery/opentargets-database/SKILL.md- Versions recorded
- 3
- Latest version
- git:20260522.d4a4f76, committed May 22, 2026
- First version recorded
- Feb 18, 2026
- Size
- 20,412 bytes
- Repository stars
- 381
- License
- a license file GitHub does not identify
Query Open Targets GraphQL API for target-disease associations, evidence, drug links, safety. Search targets by gene, diseases by EFO ID; scores from 20+ sources, drug mechanisms, tractability. For ChEMBL use chembl-database-bioactivity; for trials use clinicaltrials-database-search.
Collected from public GitHub. Every version is saved exactly as it was and never changes. Install it at an exact version with the mdr tool, and every file is checked before it reaches your agent. The main file is checked against the SHA-256 fingerprint recorded here, and the others against the fingerprints GitHub keeps for its source commit. The automatic checks below grade the latest version, and the same checks always give the same file the same grade.
What the file says
# Open Targets Platform Database ## Overview Open Targets Platform integrates evidence from genetics, genomics, literature, and drug databases to systematically score target-disease associations for 60,000+ targets and 20,000+ diseases/phenotypes. The public GraphQL API (no authentication required) provides access to association scores, evidence from 20+ data sources (GWAS, ClinVar, ChEMBL, drugs, pathways, mouse models, expression), and detailed drug-target-disease triangles. ## When to Use - Ranking therapeutic targets for a disease by overall association score and evidence breakdown - Finding all diseases associated with a gene of interest and their confidence scores - Retrieving approved and investigational drugs for a target, with mechanism of action and clinical phase - Assessing target druggability and tractability (small molecule, antibody, PROTAC likelihood) - Pulling genetic association evidence (GWAS hits, variant-to-gene mappings) for a target-disease pair - Exploring safety/adverse event data for a drug target from FAERS and literature - For bioactivity IC50/Ki data use `chembl-database-bioactivity`; for clinical trial details use `clinicaltrials-database-search` …
Read the whole file at its exact version.
How to install
mdr add jaechang-hits/sciagent-skills/opentargets-database@sha256:c389b929a5dcbed9The line at the top of this page pins the label git:20260522.d4a4f76, which is what most people want. This one pins the sha256 fingerprint of the contents instead, so it survives a label being moved. Either way the exact version is written to mdr.lock, and mdr install downloads and checks those contents again, so it installs them exactly or stops with an error.
[](https://markdownregistry.com/a/art_yzece6ifsckqf7ia)
1 badge image fetches in 30 days. What the badge shows.
Versions
The registry has recorded 3 versions of this file, between Feb 18, 2026 and May 22, 2026, about one every 46 days.
| version | committed | commit | size | audit | |
|---|---|---|---|---|---|
| git:20260522.d4a4f76 latest | 2026-05-22 | d4a4f76 | 20,412 B | A | view · diff |
| git:20260428.81ea2d2 | 2026-04-28 | 81ea2d2 | 19,605 B | A | view · diff |
| git:20260218.8df1694 | 2026-02-18 | 8df1694 | 19,704 B | A | view |
Audit of the latest version
- pass: Frontmatter block present
- pass: Frontmatter declares a name
- pass: Frontmatter declares a description
- pass: Size between 200 bytes and 200 KB (20412 bytes)
- pass: No zero-width or bidi control characters
- pass: No instruction hidden inside an HTML comment
- pass: No link to an exfiltration or paste host
- pass: No credential-shaped string
- pass: No instruction to send local credentials anywhere
- pass: No text hidden with inline styles
- pass: No prompt-injection phrasing
- pass: No curl or wget piped into a shell
- pass: No recursive delete of root, home or parent
- pass: No instruction to read or print local credentials
- pass: No base64 blob over 200 characters
- pass: No link to a raw IP address
- pass: No script tag
Source
jaechang-hits/sciagent-skills · 381 stars · license a license file GitHub does not identify · pushed 2026-10-16 · branch main
API
GET https://markdownregistry.com/api/v1/artifacts/art_yzece6ifsckqf7ia GET https://markdownregistry.com/api/v1/resolve?ref=jaechang-hits/sciagent-skills/opentargets-database GET https://markdownregistry.com/api/v1/blob/c389b929a5dcbed905c52db4a76c34379cfd2c482b2b82a6f2b0ff2ae25db8e6
Your AI assistant does the legwork. You hear about the deals worth your word. Hand yours the standing instructions at modelranch.com and it joins the network that reads files like this one.
Guides: the SKILL.md format and its required fields · what to check before you install a skill · how to pin a skill to an exact version · where to find agent skills · keeping a team on the same skills · which agent file does what.