openfold3 SKILL.md skillA
openfold3 from aipoch/open-science is an agent skill: a SKILL.md folder an AI agent loads when a task calls for it.
mdr add aipoch/open-science/openfold3@git:20260814.c9a70d8Pins git:20260814.c9a70d8 in mdr.lock. Pin the fingerprint instead.
- Audit grade
- A, 17 of 17 checks passed
- Kind
- SKILL.md skill
- Repository
- aipoch/open-science
- Path
resources/skills/openfold3/SKILL.md- Versions recorded
- 2
- Latest version
- git:20260814.c9a70d8, committed Aug 14, 2026
- First version recorded
- Jul 14, 2026
- Size
- 10,079 bytes
- Repository stars
- 5,279
- License
- Apache-2.0
Structure prediction using OpenFold3, an open-weights PyTorch reproduction of AlphaFold3 from the AlQuraishi Lab. Use this skill when predicting protein/nucleic-acid/ligand complex structures with an Apache-2.0-licensed AF3 reimplementation.
Collected from public GitHub. Every version is saved exactly as it was and never changes. Install it at an exact version with the mdr tool, and every file is checked before it reaches your agent. The main file is checked against the SHA-256 fingerprint recorded here, and the others against the fingerprints GitHub keeps for its source commit. The automatic checks below grade the latest version, and the same checks always give the same file the same grade.
What the file says
# OpenFold3 Structure Prediction ## Prerequisites | Requirement | Minimum | Recommended | | -------------- | ------- | ----------- | | Python | 3.10+ | 3.11 | | CUDA | 12.1+ | 12.4+ | | GPU VRAM | 24GB | 80GB (H100) | | RAM | 32GB | 64GB | | Disk (weights) | 3GB | - | ## How to run ### Installation ```bash pip install 'openfold3[cuequivariance]==0.4.1' ``` The default attention kernel is DeepSpeed `DS4Sci_EvoformerAttention`. If DeepSpeed is unavailable, switch to the cuEquivariance triangle kernels (no build-from-source) by overriding the eval memory settings in `model_config.py` (`use_deepspeed_evo_attention: False`, `use_cueq_triangle_kernels: True`). Some pre-built environments already ship this override; check before re-patching. ### Weights Apache-2.0, ~2.3 GB from HF `OpenFold/OpenFold3`. The repo is **gated** (auto-approval) — accept the access form on the HF model page and authenticate (`huggingface-cli login` or `HF_TOKEN`) before downloading: ```bash export OPENFOLD_CACHE=~/.openfold3 huggingface-cli download OpenFold/OpenFold3 checkpoints/of3-p2-155k.pt \ …
Read the whole file at its exact version.
How to install
mdr add aipoch/open-science/openfold3@sha256:5239e7c71cbd92bcThe line at the top of this page pins the label git:20260814.c9a70d8, which is what most people want. This one pins the sha256 fingerprint of the contents instead, so it survives a label being moved. Either way the exact version is written to mdr.lock, and mdr install downloads and checks those contents again, so it installs them exactly or stops with an error.
[](https://markdownregistry.com/a/art_5rtpt66enosdp2wp)
4 badge image fetches in 30 days. What the badge shows.
Versions
The registry has recorded 2 versions of this file, between Jul 14, 2026 and Aug 14, 2026, about one every 31 days.
| version | committed | commit | size | audit | |
|---|---|---|---|---|---|
| git:20260814.c9a70d8 latest | 2026-08-14 | c9a70d8 | 10,079 B | A | view · diff |
| git:20260714.a2a3282 | 2026-07-14 | a2a3282 | 7,378 B | A | view |
Audit of the latest version
- pass: Frontmatter block present
- pass: Frontmatter declares a name
- pass: Frontmatter declares a description
- pass: Size between 200 bytes and 200 KB (10079 bytes)
- pass: No zero-width or bidi control characters
- pass: No instruction hidden inside an HTML comment
- pass: No link to an exfiltration or paste host
- pass: No credential-shaped string
- pass: No instruction to send local credentials anywhere
- pass: No text hidden with inline styles
- pass: No prompt-injection phrasing
- pass: No curl or wget piped into a shell
- pass: No recursive delete of root, home or parent
- pass: No instruction to read or print local credentials
- pass: No base64 blob over 200 characters
- pass: No link to a raw IP address
- pass: No script tag
Source
aipoch/open-science · 5,279 stars · license Apache-2.0 · pushed 2026-10-19 · branch main
API
GET https://markdownregistry.com/api/v1/artifacts/art_5rtpt66enosdp2wp GET https://markdownregistry.com/api/v1/resolve?ref=aipoch/open-science/openfold3 GET https://markdownregistry.com/api/v1/blob/5239e7c71cbd92bc35118b7f426318a656c505c97ab1657d018c8103d449b158
Your AI assistant does the legwork. You hear about the deals worth your word. Hand yours the standing instructions at modelranch.com and it joins the network that reads files like this one.
Guides: the SKILL.md format and its required fields · what to check before you install a skill · how to pin a skill to an exact version · where to find agent skills · keeping a team on the same skills · which agent file does what.
More from aipoch/open-science
Every file in aipoch/open-science