hypothesis-generation SKILL.md skillA
hypothesis-generation from jaechang-hits/sciagent-skills is an agent skill: a SKILL.md folder an AI agent loads when a task calls for it.
mdr add jaechang-hits/sciagent-skills/hypothesis-generation@git:20260528.a0c28a2Pins git:20260528.a0c28a2 in mdr.lock. Pin the fingerprint instead.
- Audit grade
- A, 17 of 17 checks passed
- Kind
- SKILL.md skill
- Repository
- jaechang-hits/sciagent-skills
- Path
skills/scientific-writing/hypothesis-generation/SKILL.md- Versions recorded
- 1
- Latest version
- git:20260528.a0c28a2, committed May 28, 2026
- Size
- 10,669 bytes
- Repository stars
- 381
- License
- a license file GitHub does not identify
Structured hypothesis formulation: turn observations into testable hypotheses with predictions, propose mechanisms, design experiments. Follows the scientific method. Use scientific-brainstorming for open ideation; hypogenic for automated LLM hypothesis testing on datasets.
Collected from public GitHub. Every version is saved exactly as it was and never changes. Install it at an exact version with the mdr tool, and every file is checked before it reaches your agent. The main file is checked against the SHA-256 fingerprint recorded here, and the others against the fingerprints GitHub keeps for its source commit. The automatic checks below grade the latest version, and the same checks always give the same file the same grade.
What the file says
# Scientific Hypothesis Generation ## Overview Hypothesis generation is a systematic process for developing testable mechanistic explanations from observations. This knowhow covers the full cycle: from understanding a phenomenon through literature synthesis, generating competing hypotheses, evaluating hypothesis quality, designing experimental tests, and formulating testable predictions. ## Key Concepts ### 1. Hypothesis vs Observation vs Prediction - **Observation**: A factual statement about what was measured or seen (e.g., "Drug X reduces tumor size in mice") - **Hypothesis**: A proposed mechanistic explanation for the observation (e.g., "Drug X inhibits angiogenesis via VEGF pathway blockade, reducing tumor nutrient supply") - **Prediction**: A testable consequence of the hypothesis (e.g., "VEGF levels should decrease after Drug X treatment; tumors in VEGF-knockout mice should show no additional effect") Good hypotheses are mechanistic (explain HOW/WHY), not descriptive (restate WHAT). ### 2. Hypothesis Quality Criteria | Criterion | Definition | Example of Strong | Example of Weak | |-----------|-----------|-------------------|-----------------| …
Read the whole file at its exact version.
How to install
mdr add jaechang-hits/sciagent-skills/hypothesis-generation@sha256:43c4c6065fc21a64The line at the top of this page pins the label git:20260528.a0c28a2, which is what most people want. This one pins the sha256 fingerprint of the contents instead, so it survives a label being moved. Either way the exact version is written to mdr.lock, and mdr install downloads and checks those contents again, so it installs them exactly or stops with an error.
[](https://markdownregistry.com/a/art_jugzfgm4qmhuhvez)
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Versions
The registry has recorded 1 version of this file, committed on May 28, 2026.
Audit of the latest version
- pass: Frontmatter block present
- pass: Frontmatter declares a name
- pass: Frontmatter declares a description
- pass: Size between 200 bytes and 200 KB (10669 bytes)
- pass: No zero-width or bidi control characters
- pass: No instruction hidden inside an HTML comment
- pass: No link to an exfiltration or paste host
- pass: No credential-shaped string
- pass: No instruction to send local credentials anywhere
- pass: No text hidden with inline styles
- pass: No prompt-injection phrasing
- pass: No curl or wget piped into a shell
- pass: No recursive delete of root, home or parent
- pass: No instruction to read or print local credentials
- pass: No base64 blob over 200 characters
- pass: No link to a raw IP address
- pass: No script tag
Source
jaechang-hits/sciagent-skills · 381 stars · license a license file GitHub does not identify · pushed 2026-10-16 · branch main
API
GET https://markdownregistry.com/api/v1/artifacts/art_jugzfgm4qmhuhvez GET https://markdownregistry.com/api/v1/resolve?ref=jaechang-hits/sciagent-skills/hypothesis-generation GET https://markdownregistry.com/api/v1/blob/43c4c6065fc21a64652ec3cfb9c5dfe51be6d56c484ed68085ba7d248eac6fb9
Your AI assistant does the legwork. You hear about the deals worth your word. Hand yours the standing instructions at modelranch.com and it joins the network that reads files like this one.
Guides: the SKILL.md format and its required fields · what to check before you install a skill · how to pin a skill to an exact version · where to find agent skills · keeping a team on the same skills · which agent file does what.
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