analytical-method-validation SKILL.md skillA
analytical-method-validation from k-dense-ai/scientific-agent-skills is an agent skill: a SKILL.md folder an AI agent loads when a task calls for it.
mdr add k-dense-ai/scientific-agent-skills/analytical-method-validation@v2.0Pins v2.0 in mdr.lock. Pin the fingerprint instead.
- Audit grade
- A, 17 of 17 checks passed
- Kind
- SKILL.md skill
- Repository
- k-dense-ai/scientific-agent-skills
- Path
skills/analytical-method-validation/SKILL.md- Versions recorded
- 6
- Latest version
- v2.0, committed Oct 1, 2026
- First version recorded
- Jul 27, 2026
- Size
- 19,873 bytes
- Repository stars
- 53,159
- License
- MIT
Plans, executes, and documents validation, verification, and transfer of analytical procedures under the governing framework - ICH Q2(R2) and Q14, USP <1220>/<1225>/<1226>, ICH M10 bioanalytical, CLSI EP, or ISO/IEC 17025. Use for HPLC, LC-MS/MS, GC, CE, ICP-MS, dissolution, qNMR, qPCR, NIR, and ligand binding or cell-based assays whenever the question is whether a procedure is fit for its intended purpose. Triggers include "method validation", "analytical method validation", "AMV…
Collected from public GitHub. Every version is saved exactly as it was and never changes. Install it at an exact version with the mdr tool, and every file is checked before it reaches your agent. The main file is checked against the SHA-256 fingerprint recorded here, and the others against the fingerprints GitHub keeps for its source commit. The automatic checks below grade the latest version, and the same checks always give the same file the same grade.
What the file says
# Analytical Method Validation ## When to use Any time the question is whether an analytical procedure is fit for its intended purpose: designing a validation study, evaluating validation data, verifying a compendial procedure, transferring a procedure to another laboratory or instrument, or defending any of these in a report. ## The two rules **1. Establish which framework governs before designing anything.** The same assay validates differently under ICH Q2(R2), USP <1225>, ICH M10, CLSI EP, and ISO/IEC 17025. They differ in which characteristics are required, how the studies are laid out, and whether numeric acceptance criteria are supplied at all. Blending them produces a protocol that satisfies none of them. **2. State acceptance criteria before collecting data.** Criteria chosen after seeing results are not acceptance criteria, and deciding them post hoc is a standing audit finding. ICH Q2(R2) deliberately supplies almost no numeric criteria — they have to come from the specification, the analytical target profile (ICH Q14 section 3), or development data. ICH M10 is the exception: it …
Read the whole file at its exact version.
How to install
mdr add k-dense-ai/scientific-agent-skills/analytical-method-validation@sha256:7c2cd278bd397f0fThe line at the top of this page pins the label v2.0, which is what most people want. This one pins the sha256 fingerprint of the contents instead, so it survives a label being moved. Either way the exact version is written to mdr.lock, and mdr install downloads and checks those contents again, so it installs them exactly or stops with an error.
[](https://markdownregistry.com/a/art_pey2g7sanh7gcc6p)
4 badge image fetches in 30 days. What the badge shows.
Versions
The registry has recorded 6 versions of this file, between Jul 27, 2026 and Oct 1, 2026, about one every 13 days.
| version | committed | commit | size | audit | |
|---|---|---|---|---|---|
| v2.0 latest | 2026-10-01 | a92663a | 19,873 B | A | view · diff |
| v1.4 | 2026-09-30 | 32960cd | 17,558 B | A | view · diff |
| v1.3 | 2026-09-30 | aa57b2d | 17,558 B | A | view · diff |
| v1.2 | 2026-09-30 | ce9e6e9 | 17,558 B | A | view · diff |
| v1.1 | 2026-09-02 | 1e5eeff | 17,141 B | A | view · diff |
| v1.0 | 2026-07-27 | 844f4a3 | 16,183 B | A | view |
Audit of the latest version
- pass: Frontmatter block present
- pass: Frontmatter declares a name
- pass: Frontmatter declares a description
- pass: Size between 200 bytes and 200 KB (19873 bytes)
- pass: No zero-width or bidi control characters
- pass: No instruction hidden inside an HTML comment
- pass: No link to an exfiltration or paste host
- pass: No credential-shaped string
- pass: No instruction to send local credentials anywhere
- pass: No text hidden with inline styles
- pass: No prompt-injection phrasing
- pass: No curl or wget piped into a shell
- pass: No recursive delete of root, home or parent
- pass: No instruction to read or print local credentials
- pass: No base64 blob over 200 characters
- pass: No link to a raw IP address
- pass: No script tag
Source
k-dense-ai/scientific-agent-skills · 53,159 stars · license MIT · pushed 2026-10-19 · branch main
API
GET https://markdownregistry.com/api/v1/artifacts/art_pey2g7sanh7gcc6p GET https://markdownregistry.com/api/v1/resolve?ref=k-dense-ai/scientific-agent-skills/analytical-method-validation GET https://markdownregistry.com/api/v1/blob/7c2cd278bd397f0f85f4fc790b236a61190cff8799c8ece8da923342f4dc0032
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Guides: the SKILL.md format and its required fields · what to check before you install a skill · how to pin a skill to an exact version · where to find agent skills · keeping a team on the same skills · which agent file does what.
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