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bio-alignment-io skillA

bio-alignment-io is agent-read markdown (skill) from pku-yuangroup/openai4s: Read, write, and convert multiple sequence alignment files using Biopython Bio.AlignIO. Supports Clustal, PHYLIP, Stockholm, FASTA, Nexus, and other alignment formats for phylogenetics and conservation analysis. Use when reading, writing, or converting alignment file formats..

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What the file says

## Version Compatibility

Reference examples tested with: BioPython 1.83+

Before using code patterns, verify installed versions match. If versions differ:
- Python: `pip show <package>` then `help(module.function)` to check signatures

If code throws ImportError, AttributeError, or TypeError, introspect the installed
package and adapt the example to match the actual API rather than retrying.

# Alignment File I/O

Read, write, and convert multiple sequence alignment files in various formats.

## Required Import

**Goal:** Load modules for reading, writing, and manipulating multiple sequence alignments.

**Approach:** Import AlignIO for file I/O and supporting classes for programmatic alignment construction.

```python
from Bio import AlignIO
from Bio.Align import MultipleSeqAlignment
from Bio.SeqRecord import SeqRecord
from Bio.Seq import Seq
```

## Format Coverage Map

Three Python libraries cover the alignment-format space, with overlapping but non-identical support. Pick by what is actually required.

| Format | `Bio.AlignIO` | `Bio.Align` (modern) | `pyhmmer.easel` | Notes |
|--------|---------------|----------------------|-----------------|-------|
…

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A  17 of 17 checks passed. Deterministic, no model, same answer every run.
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Source

GitHub

pku-yuangroup/openai4s · 586 stars · license MIT · pushed 2026-09-23 · branch main

API

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