bio-differential-splicing SKILL.md skillA
bio-differential-splicing from pku-yuangroup/openai4s is an agent skill: a SKILL.md folder an AI agent loads when a task calls for it.
mdr add pku-yuangroup/openai4s/bio-differential-splicing@git:20260821.2d1b678Pins git:20260821.2d1b678 in mdr.lock. Pin the fingerprint instead.
- Audit grade
- A, 17 of 17 checks passed
- Kind
- SKILL.md skill
- Repository
- pku-yuangroup/openai4s
- Path
skills/bioskills/bio-alternative-splicing-differential-splicing/SKILL.md- Versions recorded
- 1
- Latest version
- git:20260821.2d1b678, committed Aug 21, 2026
- Size
- 24,690 bytes
- Repository stars
- 662
- License
- MIT
Detects differential alternative splicing between conditions using rMATS-turbo (binomial LRT on junction counts), leafcutter (Dirichlet-multinomial GLM on intron clusters), MAJIQ V3 deltapsi/HET (Bayesian posterior on LSVs), SUPPA2 (empirical-null on TPM-derived PSI), or Shiba (junction-imbalance-corrected, 2025 SOTA at low coverage). Reports FDR-corrected significance and delta PSI effect sizes. Tools differ in statistical model, annotation dependence, calibration regime, and replicate-count…
Collected from public GitHub. Every version is saved exactly as it was and never changes. Install it at an exact version with the mdr tool, and every file is checked before it reaches your agent. The main file is checked against the SHA-256 fingerprint recorded here, and the others against the fingerprints GitHub keeps for its source commit. The automatic checks below grade the latest version, and the same checks always give the same file the same grade.
What the file says
## Version Compatibility
Reference examples tested with: rMATS-turbo 4.3+, SUPPA2 2.4+, leafcutter 0.2.9+, MAJIQ 3.0+, Shiba 0.5+, STAR 2.7.11+, regtools 1.0+, pandas 2.2+, R 4.4+
Before using code patterns, verify installed versions match. If versions differ:
- Python: `pip show <package>` then `help(module.function)` to check signatures
- R: `packageVersion('<pkg>')` then `?function_name` to verify parameters
- CLI: `<tool> --version` then `<tool> --help` to confirm flags
If code throws ImportError, AttributeError, or TypeError, introspect the installed
package and adapt the example to match the actual API rather than retrying.
# Differential Splicing
Detect splicing changes between conditions. Tool choice is a decision about **statistical model**, **annotation dependence**, and **calibration regime** under the specific experimental design — not a preference. Wrong tool for the design produces uncalibrated FDR or systematic effect-size bias.
## Statistical Model Taxonomy
| Tool | Model | Test statistic | Min reps per group | Calibration regime | Fails when |
|------|-------|-----------------|---------------------|---------------------|------------|
…Read the whole file at its exact version.
How to install
mdr add pku-yuangroup/openai4s/bio-differential-splicing@sha256:60cb9590f3bc9611The line at the top of this page pins the label git:20260821.2d1b678, which is what most people want. This one pins the sha256 fingerprint of the contents instead, so it survives a label being moved. Either way the exact version is written to mdr.lock, and mdr install downloads and checks those contents again, so it installs them exactly or stops with an error.
[](https://markdownregistry.com/a/art_3i4o46deyxq6i4y4)
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Versions
The registry has recorded 1 version of this file, committed on Aug 21, 2026.
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- pass: No recursive delete of root, home or parent
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Source
pku-yuangroup/openai4s · 662 stars · license MIT · pushed 2026-11-03 · branch main
API
GET https://markdownregistry.com/api/v1/artifacts/art_3i4o46deyxq6i4y4 GET https://markdownregistry.com/api/v1/resolve?ref=pku-yuangroup/openai4s/bio-differential-splicing GET https://markdownregistry.com/api/v1/blob/60cb9590f3bc961188c411bd9fbb30e422d750fdd1c60e639002dfe017cfcf19
Your AI assistant does the legwork. You hear about the deals worth your word. Hand yours the standing instructions at modelranch.com and it joins the network that reads files like this one.
Guides: the SKILL.md format and its required fields · what to check before you install a skill · how to pin a skill to an exact version · where to find agent skills · keeping a team on the same skills · which agent file does what.