bio-differential-splicing skillA
bio-differential-splicing is agent-read markdown (skill) from pku-yuangroup/openai4s: Detects differential alternative splicing between conditions using rMATS-turbo (binomial LRT on junction counts), leafcutter (Dirichlet-multinomial GLM on intron clusters), MAJIQ V3 deltapsi/HET (Bayesian posterior on LSVs), SUPPA2 (empirical-null on TPM-derived PSI), or Shiba (junction-imbalance-corrected, 2025 SOTA at low coverage). Reports FDR-corrected significance and delta PSI effect sizes. Tools differ in statistical model, annotation dependence, calibration regime, and replicate-count re.
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What the file says
## Version Compatibility
Reference examples tested with: rMATS-turbo 4.3+, SUPPA2 2.4+, leafcutter 0.2.9+, MAJIQ 3.0+, Shiba 0.5+, STAR 2.7.11+, regtools 1.0+, pandas 2.2+, R 4.4+
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# Differential Splicing
Detect splicing changes between conditions. Tool choice is a decision about **statistical model**, **annotation dependence**, and **calibration regime** under the specific experimental design — not a preference. Wrong tool for the design produces uncalibrated FDR or systematic effect-size bias.
## Statistical Model Taxonomy
| Tool | Model | Test statistic | Min reps per group | Calibration regime | Fails when |
|------|-------|-----------------|---------------------|---------------------|------------|
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How to install
mdr add pku-yuangroup/openai4s/bio-differential-splicing@git:20260821.2d1b678mdr add pku-yuangroup/openai4s/bio-differential-splicing@sha256:60cb9590f3bc9611Pin to a label to follow the author's releases, or to a sha256 to freeze the exact bytes forever. Either way the resolved hash is written to mdr.lock, and mdr install reproduces it on any machine.
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Source
pku-yuangroup/openai4s · 586 stars · license MIT · pushed 2026-09-23 · branch main
API
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