bio-protac-degraders SKILL.md skillA
bio-protac-degraders from pku-yuangroup/openai4s is an agent skill: a SKILL.md folder an AI agent loads when a task calls for it.
mdr add pku-yuangroup/openai4s/bio-protac-degraders@git:20260821.2d1b678Pins git:20260821.2d1b678 in mdr.lock. Pin the fingerprint instead.
- Audit grade
- A, 17 of 17 checks passed
- Kind
- SKILL.md skill
- Repository
- pku-yuangroup/openai4s
- Path
skills/bioskills/bio-chemoinformatics-protac-degraders/SKILL.md- Versions recorded
- 1
- Latest version
- git:20260821.2d1b678, committed Aug 21, 2026
- Size
- 20,327 bytes
- Repository stars
- 662
- License
- MIT
Designs PROTACs, molecular glues, and bivalent degraders with explicit handling of E3 ligase choice (VHL, CRBN, IAP, MDM2, KEAP1), linker design (length, composition, rigidity), ternary complex prediction (PRosettaC, DeepTernary, AlphaFold3), cooperativity (alpha), DC50 / Dmax characterization, hook effect, and prediction-experiment reconciliation. Use when designing targeted protein degraders, planning linker SAR, predicting ternary complex stability, or building generative degrader workflows.
Collected from public GitHub. Every version is saved exactly as it was and never changes. Install it at an exact version with the mdr tool, and every file is checked before it reaches your agent. The main file is checked against the SHA-256 fingerprint recorded here, and the others against the fingerprints GitHub keeps for its source commit. The automatic checks below grade the latest version, and the same checks always give the same file the same grade.
What the file says
## Version Compatibility Reference examples tested with: PRosettaC (web service), DeepTernary research code, AlphaFold3, Boltz-1 / Boltz-2, RDKit 2024.09+, OpenMM 8.1+ (for ternary MD). Before using code patterns, verify installed versions match. If versions differ: - Python: `pip show <package>` then `help(module.function)` to check signatures If code throws ImportError, AttributeError, or TypeError, introspect the installed package and adapt the example to match the actual API rather than retrying. # PROTAC and Bivalent Degrader Design Design bifunctional molecules (PROTACs) that recruit an E3 ubiquitin ligase to a target protein, inducing target ubiquitination and proteasomal degradation. PROTACs differ from traditional drugs: a productive **ternary complex** (target + PROTAC + E3) is required, not just target binding. The modality has produced clinical programs, but their development and regulatory status changes rapidly and must be checked from current sources. PROTAC design balances **target ligand binding**, **E3 ligand binding**, **linker geometry** (length, rigidity, chemistry), **cooperativity**, **dose-dependent ternary-complex formation**, and **cell… …
Read the whole file at its exact version.
How to install
mdr add pku-yuangroup/openai4s/bio-protac-degraders@sha256:c9fb1bb7d9cbf06fThe line at the top of this page pins the label git:20260821.2d1b678, which is what most people want. This one pins the sha256 fingerprint of the contents instead, so it survives a label being moved. Either way the exact version is written to mdr.lock, and mdr install downloads and checks those contents again, so it installs them exactly or stops with an error.
[](https://markdownregistry.com/a/art_ben6h7azjj4r4rkt)
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Versions
The registry has recorded 1 version of this file, committed on Aug 21, 2026.
Audit of the latest version
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- pass: No instruction to read or print local credentials
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- pass: No script tag
Source
pku-yuangroup/openai4s · 662 stars · license MIT · pushed 2026-11-03 · branch main
API
GET https://markdownregistry.com/api/v1/artifacts/art_ben6h7azjj4r4rkt GET https://markdownregistry.com/api/v1/resolve?ref=pku-yuangroup/openai4s/bio-protac-degraders GET https://markdownregistry.com/api/v1/blob/c9fb1bb7d9cbf06f75eb0f7db7827b76cd6ae285da5d1b9775f43d9b5fe299e2
Your AI assistant does the legwork. You hear about the deals worth your word. Hand yours the standing instructions at modelranch.com and it joins the network that reads files like this one.
Guides: the SKILL.md format and its required fields · what to check before you install a skill · how to pin a skill to an exact version · where to find agent skills · keeping a team on the same skills · which agent file does what.