bio-causal-genomics-effector-gene-prioritization SKILL.md skillA
bio-causal-genomics-effector-gene-prioritization from pku-yuangroup/openai4s is an agent skill: a SKILL.md folder an AI agent loads when a task calls for it.
mdr add pku-yuangroup/openai4s/bio-causal-genomics-effector-gene-prioritization@git:20260821.2d1b678Pins git:20260821.2d1b678 in mdr.lock. Pin the fingerprint instead.
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- Kind
- SKILL.md skill
- Repository
- pku-yuangroup/openai4s
- Path
skills/bioskills/bio-causal-genomics-effector-gene-prioritization/SKILL.md- Versions recorded
- 1
- Latest version
- git:20260821.2d1b678, committed Aug 21, 2026
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- 662
- License
- MIT
Maps GWAS-implicated loci to candidate effector (causal) genes by integrating variant-to-gene (V2G) features via Open Targets L2G (Mountjoy 2021), MAGMA gene-based association (de Leeuw 2015), FUMA SNP2GENE, cS2G combined SNP-to-gene scores (Gazal 2022), Polygenic Priority Scores (PoPS, Weeks 2023), FLAMES, INQUISIT, DEPICT, and enhancer-gene predictors (ABC, ENCODE-rE2G). Use when narrowing a GWAS lead locus to a candidate causal gene, picking between proximity, eQTL-based, and…
Collected from public GitHub. Every version is saved exactly as it was and never changes. Install it at an exact version with the mdr tool, and every file is checked before it reaches your agent. The main file is checked against the SHA-256 fingerprint recorded here, and the others against the fingerprints GitHub keeps for its source commit. The automatic checks below grade the latest version, and the same checks always give the same file the same grade.
What the file says
## Version Compatibility
Reference examples tested with: MAGMA 1.10+ (cncr.nl/research/magma), FUMA web platform v1.6+ (fuma.ctglab.nl), Open Targets Genetics API (REST + GraphQL, June 2024 release), PoPS (head of `FinucaneLab/pops`, 2024), cS2G pre-computed scores (Zenodo record 7754032, Gazal 2022), ABC-Enhancer-Gene-Prediction 0.2.2+, ENCODE-rE2G v1.0+ (Gschwind 2023 preprint), DEPICT v1 rel194, INQUISIT (Fachal 2020 supplementary), Python 3.9-3.11, R 4.3+, PLINK 1.9 + PLINK 2.0.
Before using code patterns, verify installed versions match. If versions differ:
- CLI: `magma --help` to confirm gene-window, gene-annot, and gene-set flag names
- Python: `pip show gentropy`; introspect endpoints at `api.platform.opentargets.org/api/v4/graphql`
- R: `packageVersion('coloc')` etc. for upstream evidence integration
If a script throws an error about an argument that has moved (e.g. an Open Targets endpoint renamed during a release) or a model file schema change, introspect the installed tool and adapt rather than retrying. Open Targets Genetics deprecated the standalone Genetics Portal in 2024 in favour of the integrated platform; verify endpoint URLs at the time of use.
…Read the whole file at its exact version.
How to install
mdr add pku-yuangroup/openai4s/bio-causal-genomics-effector-gene-prioritization@sha256:6f3d1f3833aff4f2The line at the top of this page pins the label git:20260821.2d1b678, which is what most people want. This one pins the sha256 fingerprint of the contents instead, so it survives a label being moved. Either way the exact version is written to mdr.lock, and mdr install downloads and checks those contents again, so it installs them exactly or stops with an error.
[](https://markdownregistry.com/a/art_etl4mxi7ze2ym74n)
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Versions
The registry has recorded 1 version of this file, committed on Aug 21, 2026.
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Source
pku-yuangroup/openai4s · 662 stars · license MIT · pushed 2026-11-03 · branch main
API
GET https://markdownregistry.com/api/v1/artifacts/art_etl4mxi7ze2ym74n GET https://markdownregistry.com/api/v1/resolve?ref=pku-yuangroup/openai4s/bio-causal-genomics-effector-gene-prioritization GET https://markdownregistry.com/api/v1/blob/6f3d1f3833aff4f266e3da2cb46410166ebf2a0d9357858eca06931a5b76c7ec
Your AI assistant does the legwork. You hear about the deals worth your word. Hand yours the standing instructions at modelranch.com and it joins the network that reads files like this one.
Guides: the SKILL.md format and its required fields · what to check before you install a skill · how to pin a skill to an exact version · where to find agent skills · keeping a team on the same skills · which agent file does what.