bio-causal-genomics-transcriptome-wide-association SKILL.md skillA
bio-causal-genomics-transcriptome-wide-association from pku-yuangroup/openai4s is an agent skill: a SKILL.md folder an AI agent loads when a task calls for it.
mdr add pku-yuangroup/openai4s/bio-causal-genomics-transcriptome-wide-association@git:20260821.2d1b678Pins git:20260821.2d1b678 in mdr.lock. Pin the fingerprint instead.
- Audit grade
- A, 17 of 17 checks passed
- Kind
- SKILL.md skill
- Repository
- pku-yuangroup/openai4s
- Path
skills/bioskills/bio-causal-genomics-transcriptome-wide-association/SKILL.md- Versions recorded
- 1
- Latest version
- git:20260821.2d1b678, committed Aug 21, 2026
- Size
- 42,452 bytes
- Repository stars
- 662
- License
- MIT
Performs gene-level association from GWAS summary statistics via genetically predicted tissue expression using FUSION, PrediXcan, S-PrediXcan, S-MultiXcan, UTMOST, MOSTWAS, kTWAS, EpiXcan, TIGAR-V2, and probabilistic fine-mapping with FOCUS and MA-FOCUS. Use when running TWAS from GWAS sumstats, prioritising candidate causal genes from a GWAS lead locus, picking single-tissue vs cross-tissue models, identifying LD-induced TWAS false positives, choosing ancestry-matched prediction weights…
Collected from public GitHub. Every version is saved exactly as it was and never changes. Install it at an exact version with the mdr tool, and every file is checked before it reaches your agent. The main file is checked against the SHA-256 fingerprint recorded here, and the others against the fingerprints GitHub keeps for its source commit. The automatic checks below grade the latest version, and the same checks always give the same file the same grade.
What the file says
## Version Compatibility Reference examples tested with: FUSION (head of `gusevlab/fusion_twas`, scripts dated 2023+), MetaXcan / S-PrediXcan / S-MultiXcan 0.7.5+ (`hakyimlab/MetaXcan`), PrediXcan model files from PredictDB (GTEx v8 elastic-net + MASHR), UTMOST (head of `Joker-Jerome/UTMOST`), pyfocus 0.8+ (`bogdanlab/focus`), MA-FOCUS (head of `mancusolab/ma-focus`), TIGAR-V2 (head of `yanglab-emory/TIGAR`), PLINK 1.9 + PLINK 2.0, R 4.3+, Python 3.9-3.11. Before using code patterns, verify installed versions match. If versions differ: - R: `Rscript --version`; for FUSION scripts inspect `--help` flags directly in the source - Python: `pip show pyfocus` (MetaXcan is git-cloned, not on PyPI) then `SPrediXcan.py --help`, `SMulTiXcan.py --help`, `focus finemap --help` - CLI: `plink2 --version`; FUSION ships as R scripts not a binary If a script throws an error about an argument that has moved (e.g. `--gwas_file` vs `--gwas-file`) or a model database schema change, introspect the installed script with `--help` and adapt rather than retrying. PredictDB model file paths change with GTEx version; pin the version explicitly in scripts. # Transcriptome-Wide Association …
Read the whole file at its exact version.
How to install
mdr add pku-yuangroup/openai4s/bio-causal-genomics-transcriptome-wide-association@sha256:0a032ddd49e2c5d6The line at the top of this page pins the label git:20260821.2d1b678, which is what most people want. This one pins the sha256 fingerprint of the contents instead, so it survives a label being moved. Either way the exact version is written to mdr.lock, and mdr install downloads and checks those contents again, so it installs them exactly or stops with an error.
[](https://markdownregistry.com/a/art_lkhi4lmig5m5weww)
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Versions
The registry has recorded 1 version of this file, committed on Aug 21, 2026.
Audit of the latest version
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Source
pku-yuangroup/openai4s · 662 stars · license MIT · pushed 2026-11-03 · branch main
API
GET https://markdownregistry.com/api/v1/artifacts/art_lkhi4lmig5m5weww GET https://markdownregistry.com/api/v1/resolve?ref=pku-yuangroup/openai4s/bio-causal-genomics-transcriptome-wide-association GET https://markdownregistry.com/api/v1/blob/0a032ddd49e2c5d69a9fb8d90c4db6053248ea7cdf57fde5066f7d036a79cfd5
Your AI assistant does the legwork. You hear about the deals worth your word. Hand yours the standing instructions at modelranch.com and it joins the network that reads files like this one.
Guides: the SKILL.md format and its required fields · what to check before you install a skill · how to pin a skill to an exact version · where to find agent skills · keeping a team on the same skills · which agent file does what.