bio-clinical-biostatistics-subgroup-analysis SKILL.md skillA
bio-clinical-biostatistics-subgroup-analysis from pku-yuangroup/openai4s is an agent skill: a SKILL.md folder an AI agent loads when a task calls for it.
mdr add pku-yuangroup/openai4s/bio-clinical-biostatistics-subgroup-analysis@git:20260821.2d1b678Pins git:20260821.2d1b678 in mdr.lock. Pin the fingerprint instead.
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- SKILL.md skill
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- pku-yuangroup/openai4s
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skills/bioskills/bio-clinical-biostatistics-subgroup-analysis/SKILL.md- Versions recorded
- 1
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- git:20260821.2d1b678, committed Aug 21, 2026
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- 662
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- MIT
Performs subgroup and heterogeneous treatment effect (HTE) analyses for clinical trials. Covers Mantel-Haenszel pooling, Breslow-Day, interaction tests in regression, RERI for additive interaction, modern data-adaptive HTE methods (STEPP, SIDES, causal forests, X/R-learners), Bayesian shrinkage (Dixon-Simon, MAP, EXNEX), graphical multiplicity (Bretz-Maurer), and credibility frameworks (Sun BMJ, EMA 2019). Use when analyzing treatment effects across patient subgroups for regulatory submissions…
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What the file says
## Version Compatibility
Reference examples tested with: statsmodels 0.14+, scipy 1.12+, numpy 1.26+, pandas 2.1+, matplotlib 3.8+, scikit-learn 1.4+. R packages cited: grf, policytree, causalToolbox, personalized, SIDES, stepp, gMCP, partykit, RBesT, brms.
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# Subgroup Analysis and Heterogeneous Treatment Effects
**"Analyze treatment effects across subgroups"** -> Test whether treatment effects differ across pre-specified or data-discovered subgroups using interaction tests, stratified estimators, modern data-adaptive HTE methods, or Bayesian shrinkage -- with explicit declaration of confirmatory vs exploratory intent and credibility assessment.
## The Senn Foundation -- Why Most Subgroup Claims Are Wrong
…Read the whole file at its exact version.
How to install
mdr add pku-yuangroup/openai4s/bio-clinical-biostatistics-subgroup-analysis@sha256:dafab8bd5cf165d0The line at the top of this page pins the label git:20260821.2d1b678, which is what most people want. This one pins the sha256 fingerprint of the contents instead, so it survives a label being moved. Either way the exact version is written to mdr.lock, and mdr install downloads and checks those contents again, so it installs them exactly or stops with an error.
[](https://markdownregistry.com/a/art_paydruacbu2w6rsc)
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The registry has recorded 1 version of this file, committed on Aug 21, 2026.
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Source
pku-yuangroup/openai4s · 662 stars · license MIT · pushed 2026-11-03 · branch main
API
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