folklore-variant-evidence SKILL.md skillA

folklore-variant-evidence from k-dense-ai/scientific-agent-skills is an agent skill: a SKILL.md folder an AI agent loads when a task calls for it.

Install it, pinned
mdr add k-dense-ai/scientific-agent-skills/folklore-variant-evidence@v1.2

Pins v1.2 in mdr.lock. Pin the fingerprint instead.

Audit grade
A, 17 of 17 checks passed
Kind
SKILL.md skill
Repository
k-dense-ai/scientific-agent-skills
Path
skills/folklore-variant-evidence/SKILL.md
Versions recorded
4
Latest version
v1.2, committed Oct 1, 2026
First version recorded
Sep 11, 2026
Size
13,542 bytes
Repository stars
56,497
License
MIT

Retrieves ClinGen gene-disease validity assertions for a public gene or disease, and reviews source-linked public evidence and literature for one supported GRCh38 germline nuclear SNV or simple indel through Folklore Clinical Variant Interpretation MCP. Used when a scientific agent must branch deterministically on resolved, ambiguous, not-found, invalid, unsupported, or unavailable variant outcomes; chain a resolved public variant into related literature or publication details; or preserve…

Collected from public GitHub. Every version is saved exactly as it was and never changes. Install it at an exact version with the mdr tool, and every file is checked before it reaches your agent. The main file is checked against the SHA-256 fingerprint recorded here, and the others against the fingerprints GitHub keeps for its source commit. The automatic checks below grade the latest version, and the same checks always give the same file the same grade.

What the file says

# Folklore Variant Evidence

Use Folklore Clinical Variant Interpretation MCP to retrieve structured public
variant evidence, automated variant-level ACMG/AMP decision support, provenance,
and source-linked literature for professional review. Keep the workflow limited
to public identifiers and preserve every explicit outcome state. Adapter 1.5.0 also provides ClinGen Gene-Disease Validity assertions; source coverage is bounded, not every known association.

Folklore Clinical Variant Interpretation MCP is published by Helena
Bioinformatics. Its hosted endpoint is:

```text
https://api.helena.bio/folklore/v1/mcp
```

No account or API key is required. The public Apache-2.0 adapter and contract are
available at <https://github.com/helena-bioinformatics/folklore-mcp>.

## Minimal connection example

A host without native MCP support can make the same public JSON-RPC call:

```bash
curl --silent --show-error --fail-with-body --max-time 60 \
  -X POST https://api.helena.bio/folklore/v1/mcp \
  -H 'Content-Type: application/json' \
  -H 'Accept: application/json, text/event-stream' \
  -H 'MCP-Protocol-Version: 2026-07-28' \
  -H 'Mcp-Method: tools/call' \
…

Read the whole file at its exact version.

How to install

The exact contents, by fingerprint
mdr add k-dense-ai/scientific-agent-skills/folklore-variant-evidence@sha256:134b5ea684815b99

The line at the top of this page pins the label v1.2, which is what most people want. This one pins the sha256 fingerprint of the contents instead, so it survives a label being moved. Either way the exact version is written to mdr.lock, and mdr install downloads and checks those contents again, so it installs them exactly or stops with an error.

Badge

mdr badge

[![mdr](https://markdownregistry.com/badge/art_qsgwzeayxil7k53j.svg)](https://markdownregistry.com/a/art_qsgwzeayxil7k53j)

4 badge image fetches in 30 days. What the badge shows.

Versions

The registry has recorded 4 versions of this file, between Sep 11, 2026 and Oct 1, 2026, about one every 7 days.

versioncommittedcommitsizeaudit
v1.2 latest2026-10-01 a92663a 13,542 BA view · diff
v1.12026-09-30 ce9e6e9 11,065 BA view · diff
v1.02026-09-11 049ae89 10,728 BA view · diff
v1.22026-09-11 5226f87 10,728 BA view

Audit of the latest version

A  17 of 17 checks passed. Fixed automatic checks with no AI involved, so the same checks give the same answer every run.
  • pass: Frontmatter block present
  • pass: Frontmatter declares a name
  • pass: Frontmatter declares a description
  • pass: Size between 200 bytes and 200 KB (13542 bytes)
  • pass: No zero-width or bidi control characters
  • pass: No instruction hidden inside an HTML comment
  • pass: No link to an exfiltration or paste host
  • pass: No credential-shaped string
  • pass: No instruction to send local credentials anywhere
  • pass: No text hidden with inline styles
  • pass: No prompt-injection phrasing
  • pass: No curl or wget piped into a shell
  • pass: No recursive delete of root, home or parent
  • pass: No instruction to read or print local credentials
  • pass: No base64 blob over 200 characters
  • pass: No link to a raw IP address
  • pass: No script tag

Source

GitHub

k-dense-ai/scientific-agent-skills · 56,497 stars · license MIT · pushed 2026-11-02 · branch main

API

GET https://markdownregistry.com/api/v1/artifacts/art_qsgwzeayxil7k53j
GET https://markdownregistry.com/api/v1/resolve?ref=k-dense-ai/scientific-agent-skills/folklore-variant-evidence
GET https://markdownregistry.com/api/v1/blob/134b5ea684815b99c56fadf92a1cb42d37eaca4245515278e404b8876b7acfe0

Your AI assistant does the legwork. You hear about the deals worth your word. Hand yours the standing instructions at modelranch.com and it joins the network that reads files like this one.

Guides: the SKILL.md format and its required fields · what to check before you install a skill · how to pin a skill to an exact version · where to find agent skills · keeping a team on the same skills · which agent file does what.

More from k-dense-ai/scientific-agent-skills

AGENTS.md AGENTS.md file
k-dense-ai/scientific-agent-skills · AGENTS.md
git:20261001.f7a50ed · audit A · 56,497 stars
13c-metabolic-flux SKILL.md skill
k-dense-ai/scientific-agent-skills · skills/13c-metabolic-flux/SKILL.md · Estimates intracellular metabolic fluxes from steady-state carbon-13 isotope-tracing measurements using validated atom…
v1.2 · audit A · 56,497 stars
adaptyv SKILL.md skill
k-dense-ai/scientific-agent-skills · skills/adaptyv/SKILL.md · Uses the Adaptyv Bio Foundry API and Python SDK to design protein characterization experiments, estimate costs, submit…
v1.5 · audit A · 56,497 stars
aeon SKILL.md skill
k-dense-ai/scientific-agent-skills · skills/aeon/SKILL.md · This skill should be used for time series machine learning tasks including classification, regression, clustering…
v1.3 · audit A · 56,497 stars
alphagenome SKILL.md skill
k-dense-ai/scientific-agent-skills · skills/alphagenome/SKILL.md · Looks up precomputed AlphaGenome Atlas effects for any GRCh38 single-nucleotide variant (AVI score with Phred and 18…
v1.2 · audit A · 56,497 stars
analytical-method-validation SKILL.md skill
k-dense-ai/scientific-agent-skills · skills/analytical-method-validation/SKILL.md · Plans, executes, and documents validation, verification, and transfer of analytical procedures under the governing…
v2.0 · audit A · 56,497 stars
anndata SKILL.md skill
k-dense-ai/scientific-agent-skills · skills/anndata/SKILL.md · Handles annotated matrices in single-cell analysis, .h5ad and Zarr files, and integration with the scverse ecosystem…
v1.4 · audit A · 56,497 stars
arbor SKILL.md skill
k-dense-ai/scientific-agent-skills · skills/arbor/SKILL.md · Applies Arbor Hypothesis Tree Refinement to research artifacts with repeatable evaluators, including model training…
v1.6 · audit A · 56,497 stars
arboreto SKILL.md skill
k-dense-ai/scientific-agent-skills · skills/arboreto/SKILL.md · Infers candidate gene regulatory networks from bulk or single-cell expression data using AertsLab Arboreto GRNBoost2…
v1.3 · audit A · 56,497 stars
astropy SKILL.md skill
k-dense-ai/scientific-agent-skills · skills/astropy/SKILL.md · Core Python library for astronomy and astrophysics workflows that need Astropy APIs, including units/quantities…
v1.5 · audit A · 56,497 stars
autoskill SKILL.md skill
k-dense-ai/scientific-agent-skills · skills/autoskill/SKILL.md · Analyzes user-requested Screenpipe history windows to detect repeated research workflows, match existing scientific…
v1.6 · audit A · 56,497 stars
benchling-integration SKILL.md skill
k-dense-ai/scientific-agent-skills · skills/benchling-integration/SKILL.md · Benchling Python SDK and REST API integration for registry entities, inventory, ELN entries, workflows, Benchling Apps…
v1.7 · audit A · 56,497 stars

Every file in k-dense-ai/scientific-agent-skills

Browse by kind, by grade A, or by owner.