bio-causal-genomics-genetic-correlation SKILL.md skillA
bio-causal-genomics-genetic-correlation from pku-yuangroup/openai4s is an agent skill: a SKILL.md folder an AI agent loads when a task calls for it.
mdr add pku-yuangroup/openai4s/bio-causal-genomics-genetic-correlation@git:20260821.2d1b678Pins git:20260821.2d1b678 in mdr.lock. Pin the fingerprint instead.
- Audit grade
- A, 17 of 17 checks passed
- Kind
- SKILL.md skill
- Repository
- pku-yuangroup/openai4s
- Path
skills/bioskills/bio-causal-genomics-genetic-correlation/SKILL.md- Versions recorded
- 1
- Latest version
- git:20260821.2d1b678, committed Aug 21, 2026
- Size
- 36,639 bytes
- Repository stars
- 662
- License
- MIT
Estimates bivariate genetic correlation (rg) between traits from GWAS summary statistics or individual-level genotypes using cross-trait LDSC, HDL, LAVA, rho-HESS, GREML-bivariate, Popcorn, and HDL-L. Use when quantifying shared genetic architecture between two traits, screening MR validity before causal inference, distinguishing global from locus-level rg, estimating trans-ancestry rg, separating partial from full causation via LCV gcp, or producing a STROBE-MR-compliant cross-trait…
Collected from public GitHub. Every version is saved exactly as it was and never changes. Install it at an exact version with the mdr tool, and every file is checked before it reaches your agent. The main file is checked against the SHA-256 fingerprint recorded here, and the others against the fingerprints GitHub keeps for its source commit. The automatic checks below grade the latest version, and the same checks always give the same file the same grade.
What the file says
## Version Compatibility
Reference examples tested with: LDSC v1.0.1+ (Python 3; prefer `abdenlab/ldsc-python3` v2.0.0 -- `belowlab/ldsc` v3.0.1 README states the `--h2 / --rg / --h2-cts` CLI is broken; use Docker `jtb114/ldsc:latest` for the belowlab fallback; original `bulik/ldsc` is Python 2.7 unmaintained since 2019), HDL 1.4.0+ (R; GitHub `zhenin/HDL`), LAVA 0.1.0+ (R; GitHub `josefin-werme/LAVA`), HESS 0.5.4+ (Python; huwenboshi/hess), Popcorn 1.0+ (Python; brielin/Popcorn), GCTA 1.94+ (GREML-bivariate), baselineLD_v2.2 / eur_w_ld_chr LD-score panels from alkesgroup.broadinstitute.org/LDSCORE, UKB-array SVD eigen reference for HDL.
Before using code patterns, verify installed versions match. If versions differ:
- Python: `pip show <package>` then `python3 -c 'import <module>; help(<module>)'`
- R: `packageVersion('<pkg>')` then `?function_name`
- CLI: `<tool> --version` then `<tool> --help`
If code throws an LD-score "category not found" error, an HDL reference-panel mismatch, or a LAVA locus-ID lookup failure, introspect the installed LD-score column headers and the supplied partitioning file rather than retrying with default flags.
# Genetic Correlation
…Read the whole file at its exact version.
How to install
mdr add pku-yuangroup/openai4s/bio-causal-genomics-genetic-correlation@sha256:a52d58a7422a40d9The line at the top of this page pins the label git:20260821.2d1b678, which is what most people want. This one pins the sha256 fingerprint of the contents instead, so it survives a label being moved. Either way the exact version is written to mdr.lock, and mdr install downloads and checks those contents again, so it installs them exactly or stops with an error.
[](https://markdownregistry.com/a/art_vgfl5xwqabrinz47)
4 badge image fetches in 30 days. What the badge shows.
Versions
The registry has recorded 1 version of this file, committed on Aug 21, 2026.
Audit of the latest version
- pass: Frontmatter block present
- pass: Frontmatter declares a name
- pass: Frontmatter declares a description
- pass: Size between 200 bytes and 200 KB (36639 bytes)
- pass: No zero-width or bidi control characters
- pass: No instruction hidden inside an HTML comment
- pass: No link to an exfiltration or paste host
- pass: No credential-shaped string
- pass: No instruction to send local credentials anywhere
- pass: No text hidden with inline styles
- pass: No prompt-injection phrasing
- pass: No curl or wget piped into a shell
- pass: No recursive delete of root, home or parent
- pass: No instruction to read or print local credentials
- pass: No base64 blob over 200 characters
- pass: No link to a raw IP address
- pass: No script tag
Source
pku-yuangroup/openai4s · 662 stars · license MIT · pushed 2026-11-03 · branch main
API
GET https://markdownregistry.com/api/v1/artifacts/art_vgfl5xwqabrinz47 GET https://markdownregistry.com/api/v1/resolve?ref=pku-yuangroup/openai4s/bio-causal-genomics-genetic-correlation GET https://markdownregistry.com/api/v1/blob/a52d58a7422a40d948d7094cdedddc2d29778bab2a914c37b9ded721397798db
Your AI assistant does the legwork. You hear about the deals worth your word. Hand yours the standing instructions at modelranch.com and it joins the network that reads files like this one.
Guides: the SKILL.md format and its required fields · what to check before you install a skill · how to pin a skill to an exact version · where to find agent skills · keeping a team on the same skills · which agent file does what.