bio-clinical-databases-hla-typing SKILL.md skillA
bio-clinical-databases-hla-typing from pku-yuangroup/openai4s is an agent skill: a SKILL.md folder an AI agent loads when a task calls for it.
mdr add pku-yuangroup/openai4s/bio-clinical-databases-hla-typing@git:20260821.2d1b678Pins git:20260821.2d1b678 in mdr.lock. Pin the fingerprint instead.
- Audit grade
- A, 17 of 17 checks passed
- Kind
- SKILL.md skill
- Repository
- pku-yuangroup/openai4s
- Path
skills/bioskills/bio-clinical-databases-hla-typing/SKILL.md- Versions recorded
- 1
- Latest version
- git:20260821.2d1b678, committed Aug 21, 2026
- Size
- 25,463 bytes
- Repository stars
- 662
- License
- MIT
Calls HLA class I and class II alleles at 2/4/6/8-field resolution from WGS/WES/RNA-seq/long-read data using OptiType, HLA-LA, T1K, Polysolver, HLA-HD, arcasHLA, StarPhase, or HIBAG imputation. Use when typing for HSCT, solid-organ transplant, neoantigen prediction, PGx screening (B*57:01, B*15:02, etc.), or disease-association studies, with reconciliation across tools and IPD-IMGT/HLA version mismatch handling.
Collected from public GitHub. Every version is saved exactly as it was and never changes. Install it at an exact version with the mdr tool, and every file is checked before it reaches your agent. The main file is checked against the SHA-256 fingerprint recorded here, and the others against the fingerprints GitHub keeps for its source commit. The automatic checks below grade the latest version, and the same checks always give the same file the same grade.
What the file says
## Version Compatibility Reference examples tested with: OptiType 1.3.5, HLA-LA 1.0.4, T1K 1.0.6 (Song 2023), Polysolver 4.0, HLA-HD 1.7.1, arcasHLA 0.6.0, StarPhase 1.0+ (PacBio), HIBAG 1.40+, samtools 1.19+, bwa-mem 0.7.17+. IPD-IMGT/HLA database release frequency is quarterly; tools must be re-bundled with the current release to capture new alleles (~38,000 alleles at Jan 2024; ~43,000+ by Jul 2025). Before using code patterns, verify installed versions match. If versions differ: - Python: `pip show <package>` then `help(module.function)` to check signatures - CLI: `<tool> --version` then `<tool> --help` to confirm flags If code throws ImportError, AttributeError, or TypeError, introspect the installed package and adapt the example to match the actual API rather than retrying. Tool reference-bundle vintage matters more than algorithm choice for non-European cohorts; a 2022-bundled HLA-LA will silently miss thousands of post-2022 alleles dominant in African and South Asian ancestry. # HLA Typing for Clinical Applications …
Read the whole file at its exact version.
How to install
mdr add pku-yuangroup/openai4s/bio-clinical-databases-hla-typing@sha256:ece73be29a588279The line at the top of this page pins the label git:20260821.2d1b678, which is what most people want. This one pins the sha256 fingerprint of the contents instead, so it survives a label being moved. Either way the exact version is written to mdr.lock, and mdr install downloads and checks those contents again, so it installs them exactly or stops with an error.
[](https://markdownregistry.com/a/art_vllnf453zhtov5cn)
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Versions
The registry has recorded 1 version of this file, committed on Aug 21, 2026.
Audit of the latest version
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Source
pku-yuangroup/openai4s · 662 stars · license MIT · pushed 2026-11-03 · branch main
API
GET https://markdownregistry.com/api/v1/artifacts/art_vllnf453zhtov5cn GET https://markdownregistry.com/api/v1/resolve?ref=pku-yuangroup/openai4s/bio-clinical-databases-hla-typing GET https://markdownregistry.com/api/v1/blob/ece73be29a588279cd5339b0bc46f598fd85586b074dcdf5e879d94f7eb5e2c4
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