bio-causal-genomics-proteome-mr-drug-target skillA
bio-causal-genomics-proteome-mr-drug-target is agent-read markdown (skill) from pku-yuangroup/openai4s: Runs cis-pQTL Mendelian randomization for drug-target validation using UKB-PPP (Olink), deCODE (SomaScan), Fenland, INTERVAL, ARIC, and FinnGen-PPP proteomes plus colocalization triangulation, phenome-wide on-target adverse-effect scans, cross-platform Olink/SomaScan replication, and PAV (protein-altering variant) sensitivity. Use when nominating or de-risking a drug target from plasma-proteome GWAS, mimicking pharmacological inhibition via cis-pQTL instruments, separating shared-causal from LD-.
Indexed from public GitHub and served as immutable, content-addressed versions. Install it pinned to an exact SHA-256 with the mdr CLI, and every file is verified against the hash recorded here before it reaches your agent. The deterministic audit below grades the latest version, and the same file always earns the same grade.
What the file says
## Version Compatibility
Reference examples tested with: TwoSampleMR 0.5.11+, MendelianRandomization 0.10+, MR-PRESSO 1.0+, coloc 5.2.3+, susieR 0.12.35+, ieugwasr 1.0+, plink2 2.00a5+, R 4.4+.
Before using code patterns, verify installed versions match. If versions differ:
- R: `packageVersion('<pkg>')` then `?function_name` to verify parameters
- CLI: `plink2 --version`; VEP `vep --help`
If code throws OAuth or rate-limit errors from OpenGWAS, or a missing `dataset$N` from coloc, introspect the installed API and adapt the example rather than retrying. UKB-PPP, deCODE, and Fenland summary statistics changed file layouts between 2023 and 2025; verify column headers before passing into `format_data()`.
# Proteome-Wide Drug-Target Mendelian Randomization
…Read the whole file at its exact version.
How to install
mdr add pku-yuangroup/openai4s/bio-causal-genomics-proteome-mr-drug-target@git:20260821.2d1b678mdr add pku-yuangroup/openai4s/bio-causal-genomics-proteome-mr-drug-target@sha256:1e750b081d45f217Pin to a label to follow the author's releases, or to a sha256 to freeze the exact bytes forever. Either way the resolved hash is written to mdr.lock, and mdr install reproduces it on any machine.
[](https://markdownregistry.com/a/art_xgvqkla62t4iefqh)
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Versions
Audit of the latest version
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Source
pku-yuangroup/openai4s · 586 stars · license MIT · pushed 2026-09-23 · branch main
API
GET https://markdownregistry.com/api/v1/artifacts/art_xgvqkla62t4iefqh GET https://markdownregistry.com/api/v1/resolve?ref=pku-yuangroup/openai4s/bio-causal-genomics-proteome-mr-drug-target GET https://markdownregistry.com/api/v1/blob/1e750b081d45f217d6fc557d7a73821d5750a35cf8bee07260f76fb473a10b5c
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